Organ/body-on-a-chip based on microfluidic technology for drug discovery

被引:307
作者
Kimura, Hiroshi [1 ,2 ]
Sakai, Yasuyuki [3 ,4 ]
Fujii, Teruo [4 ]
机构
[1] Tokai Univ, Sch Engn, Dept Mech Engn, 4-1-1 Kitakaname, Hiratsuka, Kanagawa 2591292, Japan
[2] Tokai Univ, Micro Nano Technol Ctr, 4-1-1 Kitakaname, Hiratsuka, Kanagawa 2591292, Japan
[3] Univ Tokyo, Grad Sch Engn, Dept Chem Syst Engn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138654, Japan
[4] Univ Tokyo, Inst Ind Sci, Int Res Ctr Integrat Biomed Syst CIBiS, Meguro Ku, 4-6-1 Komaba, Tokyo 1538505, Japan
基金
日本科学技术振兴机构;
关键词
Microfluidic device; Organ-on-a-chip; Body-on-a-chip; Drug discovery; Cell-based assay; Animal testing; ADME; CULTURE; SYSTEM; CHALLENGES; DESIGN; CELLS;
D O I
10.1016/j.dmpk.2017.11.003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Although animal experiments are indispensable for preclinical screening in the drug discovery process, various issues such as ethical considerations and species differences remain. To solve these issues, cell-based assays using human-derived cells have been actively pursued. However, it remains difficult to accurately predict drug efficacy, toxicity, and organs interactions, because cultivated cells often do not retain their original organ functions and morphologies in conventional in vitro cell culture systems. In the mTAS research field, which is a part of biochemical engineering, the technologies of organ-on-a-chip, based on microfluidic devices built using microfabrication, have been widely studied recently as a novel in vitro organ model. Since it is possible to physically and chemically mimic the in vitro environment by using microfluidic device technology, maintenance of cellular function and morphology, and replication of organ interactions can be realized using organ-on-a-chip devices. So far, functions of various organs and tissues, such as the lung, liver, kidney, and gut have been reproduced as in vitro models. Furthermore, a body-on-a-chip, integrating multi organ functions on a microfluidic device, has also been proposed for prediction of organ interactions. We herein provide a background of microfluidic systems, organ-on-a-chip, Body-on-a-chip technologies, and their challenges in the future. (c) 2017 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:43 / 48
页数:6
相关论文
共 33 条
[1]   Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling [J].
Abaci, Hasan Erbil ;
Shuler, Michael L. .
INTEGRATIVE BIOLOGY, 2015, 7 (04) :383-391
[2]   Engineered In Vitro Disease Models [J].
Benam, Kambez H. ;
Dauth, Stephanie ;
Hassell, Bryan ;
Herland, Anna ;
Jain, Abhishek ;
Jang, Kyung-Jin ;
Karalis, Katia ;
Kim, Hyun Jung ;
MacQueen, Luke ;
Mahmoodian, Roza ;
Musah, Samira ;
Torisawa, Yu-suke ;
van der Meer, Andries D. ;
Villenave, Remi ;
Yadid, Moran ;
Parker, Kevin K. ;
Ingber, Donald E. .
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 10, 2015, 10 :195-262
[3]   Microfabrication technology for vascularized tissue engineering [J].
Borenstein, JT ;
Terai, H ;
King, KR ;
Weinberg, EJ ;
Kaazempur-Mofrad, MR ;
Vacanti, JP .
BIOMEDICAL MICRODEVICES, 2002, 4 (03) :167-175
[4]  
Dehne EM, 2017, FUTUR SCI OA, V3, DOI 10.4155/fsoa-2017-0002
[5]   The use of controlled surface topography and flow-induced shear stress to influence renal epithelial cell function [J].
Frohlich, Else M. ;
Zhang, Xin ;
Charest, Joseph L. .
INTEGRATIVE BIOLOGY, 2012, 4 (01) :75-83
[6]   Tissue engineering - Current challenges and expanding opportunities [J].
Griffith, LG ;
Naughton, G .
SCIENCE, 2002, 295 (5557) :1009-+
[7]  
Huang HC, 2013, TISSUE ENG PT A, V19, P2024, DOI [10.1089/ten.tea.2012.0605, 10.1089/ten.TEA.2012.0605]
[8]   A Human Disease Model of Drug Toxicity-Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice [J].
Huh, Dongeun ;
Leslie, Daniel C. ;
Matthews, Benjamin D. ;
Fraser, Jacob P. ;
Jurek, Samuel ;
Hamilton, Geraldine A. ;
Thorneloe, Kevin S. ;
McAlexander, Michael Allen ;
Ingber, Donald E. .
SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (159)
[9]   Reconstituting Organ-Level Lung Functions on a Chip [J].
Huh, Dongeun ;
Matthews, Benjamin D. ;
Mammoto, Akiko ;
Montoya-Zavala, Martin ;
Hsin, Hong Yuan ;
Ingber, Donald E. .
SCIENCE, 2010, 328 (5986) :1662-1668
[10]   Microcirculation System with a Dialysis Part for Bioassays Evaluating Anticancer Activity and Retention [J].
Imura, Yuki ;
Yoshimura, Etsuro ;
Sato, Kiichi .
ANALYTICAL CHEMISTRY, 2013, 85 (03) :1683-1688