Breast cancer stem cells: a way to uproot cancer

被引：0

作者：

Launay, S. G. ^{[1
]}

Ginestier, C. ^{[1
]}

Birnbaum, D. ^{[1
]}

Charafe-Jauffret, E. ^{[1
]}

机构：

[1] Inst J Paoli I Calmettes, Ctr Rech Cancerol Marseille, Lab Oncol Mol, Inserm,UMR1068, F-13273 Marseille, France

来源：

ONCOLOGIE | 2012年 / 14卷 / 09期

关键词：

Stem cell; Breast cancer; ALDEHYDE DEHYDROGENASE-ACTIVITY; TUMOR-INITIATING CELLS; RETINOIC ACID; IN-VITRO; DIFFERENTIATION; PROGENITORS; METASTASIS; CARCINOMA; RADIATION; FEATURES;

D O I：

10.1007/s10269-012-2198-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In cancer stem cell (CSC) hypothesis, tumors are organized in a hierarchical model with CSC at the top of the hierarchy. CSCs display both stem cell properties (self-renewal and differentiation) and specific tumoral properties (tumorigenicity, metastatic capacity, resistance to conventional therapies). Recent works on breast cancer allow CSCs isolation and help deciphering CSC biology and targeting with specific therapies. In clinical trials, CSC biology has to be taken into account and the criteria to judge therapeutic efficiency have to change.

引用

页码：543 / 549

页数：7

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