Nitric oxide and lipid peroxidation

被引：302

作者：

Hogg, N ^{[1
]}

Kalyanaraman, B ^{[1
]}

机构：

[1] Med Coll Wisconsin, Biophys Res Inst, Milwaukee, WI 53226 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 1999年 / 1411卷 / 2-3期

关键词：

D O I：

10.1016/S0005-2728(99)00027-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide can both promote and inhibit lipid peroxidation. By itself, nitric oxide acts as a patent inhibitor of the lipid peroxidation chain reaction by scavenging propagatory lipid peroxyl radicals. In addition, nitric oxide can also inhibit many potential initiators of lipid peroxidation, such as peroxidase enzymes. However, in the presence of superoxide, nitric oxide forms peroxynitrite, a powerful oxidant capable of initiating lipid peroxidation and oxidizing lipid soluble antioxidants. The role of nitric oxide in vascular pathology is discussed. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：378 / 384

页数：7

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