Phosphate Starvation Promotes Swarming Motility and Cytotoxicity of Pseudomonas aeruginosa

被引：85
作者：
Bains, Manjeet [1 ]
Fernandez, Lucia [1 ]
Hancock, Robert E. W. [1 ]
机构：
[1] Univ British Columbia, Ctr Microbial Dis & Immun Res, Dept Microbiol & Immunol, Vancouver, BC V5Z 1M9, Canada
来源：
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2012年 / 78卷 / 18期
基金：
加拿大健康研究院;
关键词：
VIRULENCE FACTORS; SINORHIZOBIUM-MELILOTI; CYSTIC-FIBROSIS; REGULATORY GENE; MUTANT LIBRARY; PHOB; IDENTIFICATION; BIOSYNTHESIS; PAO1; ADAPTATION;
D O I：
10.1128/AEM.01015-12
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We investigated the transcriptional responses of Pseudomonas aeruginosa under phosphate-deficient (0.2 mM) conditions compared to phosphate sufficiency (1 mM). This elicited enormous transcriptional changes in genes related to phosphate acquisition, quorum sensing, chemotaxis, toxin secretion, and regulation. This dysregulation also led to increased virulence-associated phenotypes, including swarming motility and cytotoxicity.
引用
收藏
页码：6762 / 6768
页数：7
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