EFFECT OF PHONOPHORESIS ON SKIN PERMEATION OF COMMERCIAL ANTI-INFLAMMATORY GELS: SODIUM DICLOFENAC AND KETOPROFEN

被引：11

作者：

Souza, Jaqueline ^{[1
,2
]}

Meira, Alianise ^{[3
]}

Volpato, Nadia Maria ^{[3
]}

Mayorga, Paulo ^{[3
]}

Gottfried, Carmem ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Inst Hlth Basic Sci, Dept Biochem, BR-90035003 Porto Alegre, RS, Brazil

[2] Fed Univ Pampa, Fac Physiotherapy, Uruguaiana, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Fac Pharm, BR-90035003 Porto Alegre, RS, Brazil

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2013年 / 39卷 / 09期

关键词：

Ultrasound; Phonophoresis; Ketoprofen; Sodium diclofenac; Permeation; LOW-FREQUENCY SONOPHORESIS; IN-VITRO PHONOPHORESIS; THERAPEUTIC ULTRASOUND; TRANSDERMAL PERMEATION; STRATUM-CORNEUM; INERTIAL CAVITATION; DRUG-DELIVERY; PENETRATION; HYDROCORTISONE; FORMULATIONS;

D O I：

10.1016/j.ultrasmedbio.2013.02.009

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

This study evaluated the use of ultrasound in combination with the commercial anti-inflammatory drugs ketoprofen and sodium diclofenac, according to the parameters used in physiotherapy. Ketoprofen and sodium diclofenac were used in the Franz diffusion cell model adapted to an ultrasound transducer in three conditions: no ultrasound, one application of ultrasound and two applications of ultrasound. High-performance liquid chromatography was used to quantify the total amount of drug permeating skin per unit area, as well as flux and latency. The results showed that for ketoprofen, the amount of drug permeating skin and flux increased with two ultrasound applications. Permeation of sodium diclofenac decreased in the presence of ultrasound. Ultrasound parameters and drug properties must be considered in the use of phonophoresis. (E-mail: jaquelinesz@yahoo.com.br) (C) 2013 World Federation for Ultrasound in Medicine & Biology.

引用

页码：1623 / 1630

页数：8

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