Structural biology of the IL-1 superfamily: Key cytokines in the regulation of immune and inflammatory responses

被引：66

作者：

Krumm, Brian ^{[1
]}

Xiang, Yan ^{[2
]}

Deng, Junpeng ^{[1
]}

机构：

[1] Oklahoma State Univ, Dept Biochem & Mol Biol, Stillwater, OK 74078 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA

来源：

PROTEIN SCIENCE | 2014年 / 23卷 / 05期

关键词：

cytokine; receptors; antagonist; agonist; interleukin; inflammation; RECEPTOR ACCESSORY PROTEIN; INTERLEUKIN-18; BINDING-PROTEIN; SITE-DIRECTED MUTAGENESIS; LIGAND-BINDING; FUNCTIONAL EPITOPES; IL-1-BETA SECRETION; SIGNAL-TRANSDUCTION; CRYSTAL-STRUCTURE; GAMMA PRODUCTION; NATURAL-KILLER;

D O I：

10.1002/pro.2441

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1 and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regulation of its cytokine activities by antagonists.

引用

页码：526 / 538

页数：13

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