A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects

被引：276

作者：

Lang, Nora ^{[1
]}

Pereira, Maria J. ^{[2
,3
,4
]}

Lee, Yuhan ^{[2
]}

Friehs, Ingeborg ^{[1
]}

Vasilyev, Nikolay V. ^{[1
]}

Feins, Eric N. ^{[1
]}

Ablasser, Klemens ^{[1
]}

O'Cearbhaill, Eoin D. ^{[2
]}

Xu, Chenjie ^{[2
]}

Fabozzo, Assunta ^{[1
]}

Padera, Robert ^{[5
]}

Wasserman, Steve ^{[6
]}

Freudenthal, Franz ^{[7
]}

Ferreira, Lino S. ^{[3
,4
]}

Langer, Robert ^{[8
,9
]}

Karp, Jeffrey M. ^{[2
]}

del Nido, Pedro J. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Boston Childrens Hosp, Dept Cardiac Surg, Cambridge, MA 02139 USA

[2] Harvard Univ, Sch Med,Dept Med,Div Biomed Engn, Harvard Stem Cell Inst,Ctr Regenerat Therapeut, Harvard Div Hlth Sci & Technol,Brigham & Womens H, Cambridge, MA 02139 USA

[3] Univ Coimbra, Biotechnol Innovat Ctr, P-3004517 Coimbra, Portugal

[4] Univ Coimbra, Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal

[5] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[6] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[7] Kardiozentrum, Dept Pediat Cardiol, La Paz 669, Bolivia

[8] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[9] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2014年 / 6卷 / 218期

关键词：

VENTRICULAR SEPTAL-DEFECTS; LASER-TISSUE REPAIR; BIODEGRADABLE ELASTOMER; IN-VITRO; ADHESIVES; HYDROGELS; MECHANISMS; SEALANTS; CLOSURE; GELS;

D O I：

10.1126/scitranslmed.3006557

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Currently, there are no clinically approved surgical glues that are nontoxic, bind strongly to tissue, and work well within wet and highly dynamic environments within the body. This is especially relevant to minimally invasive surgery that is increasingly performed to reduce postoperative complications, recovery times, and patient discomfort. We describe the engineering of a bioinspired elastic and biocompatible hydrophobic light-activated adhesive (HLAA) that achieves a strong level of adhesion to wet tissue and is not compromised by preexposure to blood. The HLAA provided an on-demand hemostatic seal, within seconds of light application, when applied to high-pressure large blood vessels and cardiac wall defects in pigs. HLAA-coated patches attached to the interventricular septum in a beating porcine heart and resisted supraphysiologic pressures by remaining attached for 24 hours, which is relevant to intracardiac interventions in humans. The HLAA could be used for many cardiovascular and surgical applications, with immediate application in repair of vascular defects and surgical hemostasis.

引用

页数：10

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