Potentiation of artemisinin activity against chloroquine-resistant Plasmodium falciparum strains by using heme models

被引：20
作者：
Benoit-Vical, F
Robert, A
Meunier, B
机构：
[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France
[2] UFR Sci Pharmaceut, Lab Immunol & Parasitol, F-34060 Montpellier, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 10期
关键词：
D O I：
10.1128/AAC.43.10.2555
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The influence of different metalloporphyrin derivatives on the antimalarial activity of artemisinin was studied with two chloroquine-resistant strains of Plasmodium falciparum (FcB1-Colombia and FcM29-Cameroon) cultured in human erythrocytes. This potentiation study indicates that the manganese complex of meso-tetrakis(3-sulfonatophenyl)porphyrin has a significant synergistic effect on the activity of artemisinin against both Plasmodium strains.
引用
收藏
页码：2555 / 2558
页数：4
相关论文
共 21 条
[1]   REACTION OF ANTIMALARIAL ENDOPEROXIDES WITH SPECIFIC PARASITE PROTEINS [J].
ASAWAMAHASAKDA, W ;
ITTARAT, I ;
PU, YM ;
ZIFFER, H ;
MESHNICK, SR .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (08) :1854-1858
[2]   In vitro antimalarial activity of vegetal extracts used in West African traditional medicine [J].
Benoit, F ;
Valentin, A ;
Pelissier, Y ;
Diafouka, F ;
Marion, C ;
KoneBamba, D ;
Kone, M ;
Mallie, M ;
Yapo, A ;
Bastide, JM .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1996, 54 (01) :67-71
[3]  
Cumming J N, 1997, Adv Pharmacol, V37, P253
[4]   Bisbenzylisoquinolines as modulators of chloroquine resistance in Plasmodium falciparum and multidrug resistance in tumor cells [J].
Frappier, F ;
Jossang, A ;
Soudon, J ;
Calvo, F ;
Rasoanaivo, P ;
RatsimamangaUrverg, S ;
Saez, J ;
Schrevel, J ;
Grellier, P .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (06) :1476-1481
[5]  
HOFFMANN P, 1992, B SOC CHIM FR, V129, P85
[6]   THE INTERACTION OF ARTEMISININ WITH MALARIAL HEMOZOIN [J].
HONG, YL ;
YANG, YZ ;
MESHNICK, SR .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1994, 63 (01) :121-128
[7]   SYNTHESIS, STRUCTURE, AND ANTIMALARIAL ACTIVITY OF SOME ENANTIOMERICALLY PURE, CIS-FUSED CYCLOPENTENO-1,2,4-TRIOXANES [J].
JEFFORD, CW ;
KOHMOTO, S ;
JAGGI, D ;
TIMARI, G ;
ROSSIER, JC ;
RUDAZ, M ;
BARBUZZI, O ;
GERARD, D ;
BURGER, U ;
KAMALAPRIJA, P ;
MAREDA, J ;
BERNARDINELLI, G ;
MANZANARES, I ;
CANFIELD, CJ ;
FLECK, SL ;
ROBINSON, BL ;
PETERS, W .
HELVETICA CHIMICA ACTA, 1995, 78 (03) :647-662
[8]   The mode of action of the antimalarial artemisinin and its derivatives [J].
Kamchonwonggpaisan, S ;
Meshnick, SR .
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1996, 27 (04) :587-592
[9]   QINGHAOSU (ARTEMISININ) - AN ANTIMALARIAL DRUG FROM CHINA [J].
KLAYMAN, DL .
SCIENCE, 1985, 228 (4703) :1049-1055
[10]   THE ANTIMALARIAL ACTION ON PLASMODIUM-FALCIPARUM OF QINGHAOSU AND ARTESUNATE IN COMBINATION WITH AGENTS WHICH MODULATE OXIDANT STRESS [J].
KRUNGKRAI, SR ;
YUTHAVONG, Y .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1987, 81 (05) :710-714
123