Induction of Accelerated Aging in a Mouse Model

被引：50

作者：

Cai, Nanshuo ^{[1
]}

Wu, Yifan ^{[1
]}

Huang, Yan ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Guangzhou Key Lab Hlth Aging Res & State Key Lab, Sch Life Sci, MOE Key Lab Gene Funct & Regulat, Guangzhou 510275, Peoples R China

来源：

CELLS | 2022年 / 11卷 / 09期

关键词：

aging; aging-related disease; mouse model; GALACTOSE-INDUCED LIVER; CHRONIC KIDNEY-DISEASE; ACID-DEFINED DIET; CHRONIC JET-LAG; OXIDATIVE STRESS; MURINE MODEL; MITOCHONDRIAL DYSFUNCTION; ALZHEIMERS-DISEASE; SKELETAL-MUSCLE; ANIMAL-MODELS;

D O I：

10.3390/cells11091418

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

With the global increase of the elderly population, the improvement of the treatment for various aging-related diseases and the extension of a healthy lifespan have become some of the most important current medical issues. In order to understand the developmental mechanisms of aging and aging-related disorders, animal models are essential to conduct relevant studies. Among them, mice have become one of the most prevalently used model animals for aging-related studies due to their high similarity to humans in terms of genetic background and physiological structure, as well as their short lifespan and ease of reproduction. This review will discuss some of the common and emerging mouse models of accelerated aging and related chronic diseases in recent years, with the aim of serving as a reference for future application in fundamental and translational research.

引用

页数：25

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