Chimpanzee-origin adenovirus vectors as vaccine carriers

被引：76

作者：

Tatsis, N

Tesema, L

Robinson, ER

Giles-Davis, W

McCoy, K

Gao, GP

Wilson, JM

Ertl, HCJ

机构：

[1] Wistar Inst Anat & Biol, Program Immunol, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Med, Div Med Genet, Gene Therapy Program, Philadelphia, PA 19104 USA

来源：

GENE THERAPY | 2006年 / 13卷 / 05期

关键词：

adenovirus; vaccine; HIV-1;

D O I：

10.1038/sj.gt.3302675

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vaccines based on replication-defective adenoviral vectors are being developed for infectious agents and tumor-associated antigens. Early work focused on vaccines derived from a common human serotype of adenovirus, that is, adenovirus of the serotype 5 (AdHu5). Neutralizing antibodies against AdHu5 virus, present in a large percentage of the human population, dampen the efficacy of vaccines based on this carrier. To circumvent this problem, we generated vectors derived from chimpanzee adenoviruses. Here we describe some basic parameters of vectors derived from chimpanzee adenoviruses C68 and C7, including growth characteristics, yields of infectious particles, effects of additional deletions in E3 and E4 and lengths of the inserted foreign sequence as they relate to the suitability for their eventual development as vaccine carriers for clinical use.

引用

页码：421 / 429

页数：9

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