Diagnostic Value of 68Ga PSMA-11 PET/CT Imaging of Brain Tumors-Preliminary Analysis

被引：109
作者：
Sasikumar, Arun [1 ,2 ]
Joy, Ajith [1 ,2 ]
Pillai, M. R. A. [3 ]
Nanabala, Raviteja [1 ,2 ]
Anees, Muhammed K. [1 ,2 ]
Jayaprakash, P. G.
Madhavan, Jayaprakash [4 ,5 ]
Nair, Suresh [6 ]
机构：
[1] Dept Nucl Med, Trivandrum, Kerala, India
[2] PET CT KIMS DDNMRC, Trivandrum, Kerala, India
[3] Mol Grp Co, Ernakulam, Kerala, India
[4] Reg Canc Ctr, Dept Radiat Oncol, Trivandrum, Kerala, India
[5] KIMS Canc Ctr, Dept Radiat Oncol, Trivandrum, Kerala, India
[6] Sree Chitra Tirunal Inst Med Sci & Technol, Dept Neurosurg, Trivandrum, Kerala, India
来源：
CLINICAL NUCLEAR MEDICINE | 2017年 / 42卷 / 01期
关键词：
brain imaging; glioblastoma; gallium-68; PET/CT; prostate specific membrane antigen; tumor neovascularization; MEMBRANE ANTIGEN PSMA; HBED-CC PET/CT; SHOWING AVID UPTAKE; PROSTATE-CANCER; BREAST-CANCER; EXPRESSION; CARCINOMA; NEOVASCULATURE; GLIOBLASTOMA; RECURRENCE;
D O I：
10.1097/RLU.0000000000001451
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Objective: To evaluate the feasibility of using Ga-68 PSMA-11 PET/CT for imaging brain lesions and its comparison with F-18-FDG. Methods: Ten patients with brain lesions were included in the study. Five patients were treated cases of glioblastoma with suspected recurrence. F-18-FDG and Ga-68 PSMA-11 brain scans were done for these patients. Five patients were sent for assessing the nature (primary lesion/metastasis) of space occupying lesion in brain. They underwent whole body F-18-FDG PET/CT scan and a primary site elsewhere in the body was ruled out. Subsequently they underwent Ga-68 PSMA-11 brain PET/CT imaging. Target to background ratios (TBR) for the brain lesions were calculated using contralateral cerebellar uptake as background. Results: In five treated cases of glioblastoma with suspected recurrence the findings of Ga-68 PSMA-11 PET/CT showed good correlation with that of F-18-FDG PET/CT scan. Compared to the F-18-FDG, Ga-68 PSMA-11 PET/CT showed better visualization of the recurrent lesion (presence/absence) owing to its significantly high TBR. Among the five cases evaluated for lesion characterization glioma and atypical meningioma patients showed higher SUVmax in the lesion with Ga-68 PSMA-11 than with F-18-FDG and converse in cases of lymphoma. TBR was better with Ga-68 PSMA PET/CT in all cases. Conclusion: Ga-68 PSMA-11 PET/CT brain imaging is a potentially useful imaging tool in the evaluation of brain lesions. Absence of physiological uptake of Ga-68 PSMA-11 in the normal brain parenchyma results in high TBR values and consequently better visualization of metabolically active disease in brain.
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收藏
页码：E41 / E48
页数：8
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