Cytokine profiles of patients with enterohemorrhagic Escherichia coli O111-induced hemolytic-uremic syndrome

被引：27

作者：

Shimizu, Masaki ^{[1
]}

Kuroda, Mondo ^{[1
]}

Sakashita, Natsumi ^{[1
]}

Konishi, Michio ^{[2
]}

Kaneda, Hisashi ^{[3
]}

Igarashi, Noboru ^{[4
]}

Yamahana, Junya ^{[5
]}

Taneichi, Hiromichi ^{[6
]}

Kanegane, Hirokazu ^{[6
]}

Ito, Mika ^{[7
]}

Saito, Shigeru ^{[7
]}

Ohta, Kazuhide ^{[8
]}

Taniguchi, Takumi ^{[9
]}

Furuichi, Kengo ^{[10
]}

Wada, Takashi ^{[10
]}

Nakagawa, Masaru ^{[11
]}

Yokoyama, Hitoshi ^{[11
]}

Yachie, Akihiro ^{[1
]}

机构：

[1] Kanazawa Univ, Dept Pediat, Sch Med, Inst Med Pharmaceut & Hlth Sci, Kanazawa, Ishikawa 9208641, Japan

[2] Tonami Gen Hosp, Dept Pediat, Toyama, Japan

[3] Toyama City Hosp, Dept Pediat, Toyama, Japan

[4] Toyama Prefectural Cent Hosp, Dept Pediat, Toyama, Japan

[5] Toyama Prefectural Cent Hosp, Div Nephrol, Toyama, Japan

[6] Toyama Univ, Sch Med, Dept Pediat, Toyama, Japan

[7] Toyama Univ, Sch Med, Dept Obstet & Gynaecol, Toyama, Japan

[8] Kanazawa Med Ctr, Dept Pediat, Kanazawa, Ishikawa, Japan

[9] Kanazawa Univ Hosp, Intens Care Unit, Kanazawa, Ishikawa, Japan

[10] Kanazawa Univ Hosp, Div Nephrol, Kanazawa, Ishikawa, Japan

[11] Kanazawa Med Univ, Div Nephrol, Kanazawa, Ishikawa, Japan

来源：

CYTOKINE | 2012年 / 60卷 / 03期

关键词：

Cytokine; Enterohemorrhagic Escherichia coli O111; Hemolytic-uremic syndrome; SHIGA-TOXIN; INTERLEUKIN-6; CHILDREN; HUS;

D O I：

10.1016/j.cyto.2012.07.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proinflammatory cytokines are related to the pathogenesis of enterohemorrhagic Escherichia coli (EHEC) infection and hemolytic-uremic syndrome (HUS). We assessed the kinetics of the release of cytokines such as neopterin, interleukin (IL)-6, IL-8 and tumour necrosis factor (INF)-alpha and the soluble forms of type I and II TNF receptors during EHEC O111-induced HUS (EHEC O111/HUS). Fourteen patients with EHEC O111/HUS were enrolled in this study. Serum concentrations of all cytokines other than TNF-alpha were significantly elevated in patients with severe HUS compared with those in patients with mild HUS. Although serum concentrations of TNF-alpha were not significantly higher in patients with severe HUS, most patients with acute encephalopathy showed elevated TNF-alpha levels. Serum concentrations of these cytokines rapidly and markedly increased, and massive hypercytokinaemia developed 1 day before the diagnosis of HUS in patients with severe HUS. Changes in the number of white blood cells and concentration of serum lactate dehydrogenase were significantly larger between the onset of hemorrhagic colitis and the time of the diagnosis of HUS in patients with severe HUS compared with those in patients with mild HUS. Proinflammatory cytokines play an important role in the pathogenesis of EHEC infection and development of severe complications, including HUS and encephalopathy. Monitoring the cytokine profile may be useful for assessing disease activity of EHEC O111 infections. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：694 / 700

页数：7

共 28 条

[11] Risk factors for developing severe clinical course in HUS patients: a national survey in Japan [J].