Hybrid graphene oxide/polysaccharide nanocomposites with controllable surface properties and biocompatibility

被引：16

作者：

Andreeva, Tonya D. ^{[1
]}

Stoichev, Svetozar ^{[1
]}

Taneva, Stefka G. ^{[1
]}

Krastev, Rumen ^{[2
,3
]}

机构：

[1] Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Acad G Bonchev Str,Bl 21, Sofia 1113, Bulgaria

[2] Univ Tubingen NMI, Nat & Med Sci Inst, Dept Biomat, Markwiesenstr 55, D-72770 Reutlingen, Germany

[3] Reutlingen Univ, Fac Appl Chem, Alteburgstr 150, D-72762 Reutlingen, Germany

来源：

CARBOHYDRATE POLYMERS | 2018年 / 181卷

关键词：

Graphene oxide; Hyaluronan; Chitosan; Polyelectrolyte multilayers; Biocompatibility; POLYELECTROLYTE MULTILAYER FILMS; SUPER GAS BARRIER; MECHANICAL-PROPERTIES; CELL-ADHESION; OXIDE; ASSEMBLIES; DEPOSITION; COATINGS; GROWTH; WATER;

D O I：

10.1016/j.carbpol.2017.10.053

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein, a strong interdependence between the composition of hybrid graphene oxide/hyaluronan/chitosan GO/HA/Chi multilayers and their surface properties and biocompatibility was demonstrated that can be used to build up coatings with desirable and precisely tunable properties. Both the position and the abundance of GO-layers into the polymer matrix were systematically varied to draw interconnection with the growth type, thickness, morphology, roughness, hydrophilicity and biocompatibility. It was found that when deposited in-between the HA and Chi layers GO forms diffusion barrier, hindering the mobility of Chi-chains and changing the exponential film growth to linear. Incorporation of GO-layers into the biodegradable and highly hydrated HA/Chi matrix does not affect the final thickness, but has a dramatic impact on the surface morphology and roughness, which in turn tunes the hydrophilicity, protein adsorption and platelets adhesion. This provides an opportunity for various biomedical applications of the studied hybrid films as coatings with controllable surface properties.

引用

页码：78 / 85

页数：8

共 37 条

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