Evaluation of the Cytotoxic Activity of Some Brazilian Medicinal Plants

被引：43

作者：

Ribeiro, Sandra S. ^{[2
]}

de Jesus, Aline M. ^{[2
]}

dos Anjos, Charlene S. ^{[2
]}

da Silva, Thanany B. ^{[2
]}

Santos, Alan D. C. ^{[2
]}

de Jesus, Jemmyson R. ^{[2
]}

Andrade, Moacir S. ^{[2
]}

Sampaio, Tais S. ^{[2
]}

Gomes, Wesley F. ^{[2
]}

Alves, Pericles B. ^{[2
]}

Carvalho, Adriana A. ^{[3
]}

Pessoa, Claudia ^{[3
]}

de Moraes, Manoel O. ^{[3
]}

Pinheiro, Maria L. B. ^{[4
]}

Prata, Ana Paula N. ^{[5
]}

Blank, Arie F. ^{[6
]}

Silva-Mann, Renata ^{[6
]}

Moraes, Valeria R. S. ^{[2
]}

Costa, Emmanoel V. ^{[2
]}

Nogueira, Paulo Cesar L. ^{[2
]}

Bezerra, Daniel P. ^{[1
]}

机构：

[1] Univ Fed Sergipe, Dept Physiol, BR-49100000 Sao Cristovao, Sergipe, Brazil

[2] Univ Fed Sergipe, Dept Chem, BR-49100000 Sao Cristovao, Sergipe, Brazil

[3] Univ Fed Ceara, Dept Physiol & Pharmacol, Sch Med, Fortaleza, Ceara, Brazil

[4] Univ Fed Amazonas, Dept Chem, Manaus, Amazonas, Brazil

[5] Univ Fed Sergipe, Dept Biol, BR-49100000 Sao Cristovao, Sergipe, Brazil

[6] Univ Fed Sergipe, Dept Agron Engn, BR-49100000 Sao Cristovao, Sergipe, Brazil

来源：

PLANTA MEDICA | 2012年 / 78卷 / 14期

关键词：

cytotoxicity; Guatteria blepharophylla; Guatteria hispida; Jatropha curcas; Kielmeyera rugosa; Lippia gracilis; extracts; essential oil; CHEMOTHERAPEUTIC-AGENTS; CHEMICAL-CONSTITUENTS; NATURAL-PRODUCTS; CANCER;

D O I：

10.1055/s-0032-1315043

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Plants are promising sources of new bioactive compounds. The aim of this study was to investigate the cytotoxic potential of nine plants found in Brazil. The species studied were: Annona pickelii Diels (Annonaceae), Annona salzmannii A. DC. (Annonaceae), Guatteria blepharophylla Mart. (Annonaceae), Guatteria hispida (R. E. Fr.) Erkens & Maas (Annonaceae), Hancornia speciosa Gomes (Apocynaceae), Jatropha curcas L. (Euphorbiaceae), Kielmeyera rugosa Choisy (Clusiaceae), Lippia gracilis Schauer (Verbenaceae), and Hyptis calida Mart. Ex Benth (Lamiaceae). Different types of extractions from several parts of plants resulted in 43 extracts. Their cytotoxicity was tested against HCT-8 (colon carcinoma), MDA-MB-435 (melanoma), SF-295 (glioblastoma), and HL-60 (promielocitic leukemia) human tumor cell lines, using the thiazolyl blue test (MTT) assay. The active extracts were those obtained from G. blepharophylla, G. hispida, J. curcas, K. rugosa, and L. gracilis. In addition, seven compounds isolated from the active extracts were tested; among them, beta-pinene found in G. hispida and one coumarin isolated from K. rugora showed weak cytotoxic activity. In summary, this manuscript contributes to the understanding of the potentialities of Brazilian plants as sources of new anticancer drugs.

引用

页码：1601 / 1606

页数：6

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