Role of quaternary ammonium salts as new additives in the enantioselective organocatalytic β-benzylation of enals

被引：24

作者：

Duce, Sara ^{[1
]}

Mateo, Alvaro ^{[1
]}

Alonso, Ines ^{[1
]}

Garcia Ruano, Jose Luis ^{[1
]}

Belen Cid, M. ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Dept Organ Chem, E-28049 Madrid, Spain

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 42期

关键词：

ALPHA; BETA-UNSATURATED ALDEHYDES; DIARYLPROLINOL ETHERS; ASYMMETRIC-SYNTHESIS; CATALYSIS; NMR;

D O I：

10.1039/c2cc31451g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein the efficiency of quaternary ammonium salts as co-catalysts in organocatalytic Michael reactions involving iminium activation of alpha,beta-unsaturated aldehydes. The enantioselective formal benzylation of these substrates has been optimized and used to rationalize the role of the ammonium salts in these processes.

引用

页码：5184 / 5186

页数：3

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