Ventral Tegmental Area in Prodromal Alzheimer's Disease: Bridging the Gap between Mice and Humans

被引：21
作者：
D'Amelio, Marcello [1 ,2 ]
Serra, Laura [3 ]
Bozzali, Marco [3 ,4 ]
机构：
[1] Univ Campus Biomed, Unit Mol Neurosci, Dept Med, Rome, Italy
[2] IRCCS Santa Lucia Fdn, Lab Mol Neurosci, Dept Expt Neurosci, Rome, Italy
[3] IRCCS Santa Lucia Fdn, Neuroimaging Lab, Rome, Italy
[4] Univ Sussex, Brighton & Sussex Med Sch, Dept Neurosci, Brighton, E Sussex, England
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2018年 / 63卷 / 01期
关键词：
Alzheimer's disease; dopamine; hippocampus; memory; midbrain; ventral tegmental area; LOCUS-COERULEUS; PARKINSONS-DISEASE; MEMORY; CONSOLIDATION; PERSISTENCE; HIPPOCAMPUS; BRAIN;
D O I：
10.3233/JAD-180094
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease (AD) is a progressive neurological disorder characterized by several cognitive and non-cognitive symptoms, with episodic memory being the earliest and most prominently impaired cognitive function. Dopaminergic signals are required for encoding hippocampal memory for new events and the ventral tegmental area (VTA), together with the locus coeruleus, are the primary sources of dopamine acting on dopaminergic receptors in the hippocampus. With this in mind, a recent study on a validated mouse model of AD highlighted on the hippocampal dysfunction and its correlation with an early degeneration of dopaminergic neurons in the VTA. In this issue, De Marco and Venneri test the hypothesis that the volume of the VTA nucleus in humans might be associated with cognitive features of AD.
引用
收藏
页码：181 / 183
页数：3
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