The translocator protein (TSPO): A novel target for cancer chemotherapy

被引：75
作者：
Austin, Christopher J. D. [1 ]
Kahlert, Jan [1 ]
Kassiou, Michael [1 ]
Rendina, Louis M. [1 ]
机构：
[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2013年 / 45卷 / 07期
关键词：
Translocator protein; TSPO; Cancer; Apoptosis; Cell homoeostasis; PERIPHERAL BENZODIAZEPINE-RECEPTOR; 18 KDA TSPO; MITOCHONDRIAL PERMEABILITY TRANSITION; DEPENDENT ANION CHANNELS; BINDING-SITES; COLONIC ADENOCARCINOMA; CHOLESTEROL TRANSPORT; DISEASE STATES; LIGANDS; TUMORS;
D O I：
10.1016/j.biocel.2013.03.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The translocator protein (TSPO) is an 18 kDa transmembrane protein primarily found in the outer mitochondrial membrane where it forms a key part of the mitochondrial permeability transition pore (MFTP). Omnipresent in almost all tissues, TSPO up-regulation has been connected to neuronal damage and inflammation, making the protein an important bio-imaging marker for disease progression. More recently, TSPO has attracted attention as a possible molecular target for tumour imaging and chemotherapy. In this review we summarize TSPO's molecular characteristics and highlight research progress in recent years in the field of TSPO-targeted cancer diagnostics and treatments. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：1212 / 1216
页数：5
相关论文
共 41 条
  • [1] Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death
    Baines, Christopher P.
    Kaiser, Robert A.
    Sheiko, Tatiana
    Craigen, William J.
    Molkentin, Jeffery D.
    [J]. NATURE CELL BIOLOGY, 2007, 9 (05) : 550 - U122
  • [2] Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states
    Batarseh, Amani
    Papadopoulos, Vassilios
    [J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2010, 327 (1-2) : 1 - 12
  • [3] Protein Kinase Cε Regulation of Translocator Protein (18 kDa) Tspo Gene Expression Is Mediated through a MAPK Pathway Targeting STAT3 and c-Jun Transcription Factors
    Batarseh, Amani
    Li, Jiehan
    Papadopoulos, Vassilios
    [J]. BIOCHEMISTRY, 2010, 49 (23) : 4766 - 4778
  • [4] Specific binding of benzodiazepines to human breast cancer cell lines
    Beinlich, A
    Strohmeier, R
    Kaufmann, M
    Kuhl, H
    [J]. LIFE SCIENCES, 1999, 65 (20) : 2099 - 2108
  • [5] IMAGING OF BRAIN-TUMORS USING PERIPHERAL BENZODIAZEPINE RECEPTOR LIGANDS
    BLACK, KL
    IKEZAKI, K
    TOGA, AW
    [J]. JOURNAL OF NEUROSURGERY, 1989, 71 (01) : 113 - 118
  • [6] Erythrocyte peripheral type benzodiazepine receptor/voltage-dependent anion channels are upregulated by Plasmodium falciparum
    Bouyer, Guillaume
    Cueff, Anne
    Egee, Stephane
    Kmiecik, Justyna
    Maksimova, Yelena
    Glogowska, Edyta
    Gallagher, Patrick G.
    Thomas, Serge L. Y.
    [J]. BLOOD, 2011, 118 (08) : 2305 - 2312
  • [7] Braestrup C., 1977, High densities of benzodiazepine receptors in human cortical areas
  • [8] Carborane-Conjugated 2-Quinolinecarboxamide Ligands of the Translocator Protein for Boron Neutron Capture Therapy
    Cappelli, Andrea
    Valenti, Salvatore
    Mancini, Alessandra
    Giuliani, Germano
    Anzini, Maurizio
    Altieri, Saverio
    Bortolussi, Silva
    Ferrari, Cinzia
    Clerici, Anna Maria
    Zonta, Cecilia
    Carraro, Fabio
    Filippi, Irene
    Giorgi, Gianluca
    Donati, Alessandro
    Ristori, Sandra
    Vomero, Salvatore
    Concas, Alessandra
    Biggio, Giovanni
    [J]. BIOCONJUGATE CHEMISTRY, 2010, 21 (12) : 2213 - 2221
  • [9] Peripheral benzodiazepine receptors and mitochondrial function
    Casellas, P
    Galiegue, S
    Basile, AS
    [J]. NEUROCHEMISTRY INTERNATIONAL, 2002, 40 (06) : 475 - 486
  • [10] Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair
    Chen, Ming-Kai
    Guilarte, Tomas R.
    [J]. PHARMACOLOGY & THERAPEUTICS, 2008, 118 (01) : 1 - 17
12345