The translocator protein (TSPO): A novel target for cancer chemotherapy

被引：75

作者：

Austin, Christopher J. D. ^{[1
]}

Kahlert, Jan ^{[1
]}

Kassiou, Michael ^{[1
]}

Rendina, Louis M. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2013年 / 45卷 / 07期

关键词：

Translocator protein; TSPO; Cancer; Apoptosis; Cell homoeostasis; PERIPHERAL BENZODIAZEPINE-RECEPTOR; 18 KDA TSPO; MITOCHONDRIAL PERMEABILITY TRANSITION; DEPENDENT ANION CHANNELS; BINDING-SITES; COLONIC ADENOCARCINOMA; CHOLESTEROL TRANSPORT; DISEASE STATES; LIGANDS; TUMORS;

D O I：

10.1016/j.biocel.2013.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The translocator protein (TSPO) is an 18 kDa transmembrane protein primarily found in the outer mitochondrial membrane where it forms a key part of the mitochondrial permeability transition pore (MFTP). Omnipresent in almost all tissues, TSPO up-regulation has been connected to neuronal damage and inflammation, making the protein an important bio-imaging marker for disease progression. More recently, TSPO has attracted attention as a possible molecular target for tumour imaging and chemotherapy. In this review we summarize TSPO's molecular characteristics and highlight research progress in recent years in the field of TSPO-targeted cancer diagnostics and treatments. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

引用

页码：1212 / 1216

页数：5

共 41 条

[1] Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death [J].

Baines, Christopher P. ;

Kaiser, Robert A. ;

Sheiko, Tatiana ;

Craigen, William J. ;

Molkentin, Jeffery D. .

NATURE CELL BIOLOGY, 2007, 9 (05) :550-U122

[2] Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states [J].

Batarseh, Amani ;

Papadopoulos, Vassilios .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2010, 327 (1-2) :1-12

[3] Protein Kinase Cε Regulation of Translocator Protein (18 kDa) Tspo Gene Expression Is Mediated through a MAPK Pathway Targeting STAT3 and c-Jun Transcription Factors [J].

Batarseh, Amani ;

Li, Jiehan ;

Papadopoulos, Vassilios .

BIOCHEMISTRY, 2010, 49 (23) :4766-4778

[4] Specific binding of benzodiazepines to human breast cancer cell lines [J].

Beinlich, A ;

Strohmeier, R ;

Kaufmann, M ;

Kuhl, H .

LIFE SCIENCES, 1999, 65 (20) :2099-2108

[5] IMAGING OF BRAIN-TUMORS USING PERIPHERAL BENZODIAZEPINE RECEPTOR LIGANDS [J].

BLACK, KL ;

IKEZAKI, K ;

TOGA, AW .

JOURNAL OF NEUROSURGERY, 1989, 71 (01) :113-118

[6] Erythrocyte peripheral type benzodiazepine receptor/voltage-dependent anion channels are upregulated by Plasmodium falciparum [J].

Bouyer, Guillaume ;

Cueff, Anne ;

Egee, Stephane ;

Kmiecik, Justyna ;

Maksimova, Yelena ;

Glogowska, Edyta ;

Gallagher, Patrick G. ;

Thomas, Serge L. Y. .

BLOOD, 2011, 118 (08) :2305-2312

[7]

Braestrup C., 1977, High densities of benzodiazepine receptors in human cortical areas

[8] Carborane-Conjugated 2-Quinolinecarboxamide Ligands of the Translocator Protein for Boron Neutron Capture Therapy [J].

Cappelli, Andrea ;

Valenti, Salvatore ;

Mancini, Alessandra ;

Giuliani, Germano ;

Anzini, Maurizio ;

Altieri, Saverio ;

Bortolussi, Silva ;

Ferrari, Cinzia ;

Clerici, Anna Maria ;

Zonta, Cecilia ;

Carraro, Fabio ;

Filippi, Irene ;

Giorgi, Gianluca ;

Donati, Alessandro ;

Ristori, Sandra ;

Vomero, Salvatore ;

Concas, Alessandra ;

Biggio, Giovanni .

BIOCONJUGATE CHEMISTRY, 2010, 21 (12) :2213-2221

[9] Peripheral benzodiazepine receptors and mitochondrial function [J].

Casellas, P ;

Galiegue, S ;

Basile, AS .

NEUROCHEMISTRY INTERNATIONAL, 2002, 40 (06) :475-486

[10] Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair [J].

Chen, Ming-Kai ;

Guilarte, Tomas R. .

PHARMACOLOGY & THERAPEUTICS, 2008, 118 (01) :1-17

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