Polycomb group proteins and their roles in carcinogenesis

被引：2
|
作者：
Xiao LanBo [1 ,2 ,3 ]
Tao YongGuang [1 ,2 ,3 ]
Li LiLi [1 ,2 ,3 ,4 ]
Cao Ya [1 ,2 ,3 ]
机构：
[1] Cent S Univ, Xiangya Sch Med, Minist Hlth, Key Lab Carcinogenesis, Changsha 410078, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Sch Med, Minist Educ, Key Lab Carcinogenesis & Canc Invas, Changsha 410078, Hunan, Peoples R China
[3] Cent S Univ, Xiangya Sch Med, Canc Res Inst, Changsha 410078, Hunan, Peoples R China
[4] Chinese Univ Hong Kong, State Key Lab Oncol S China, Canc Epigenet Lab, Hong Kong 999077, Hong Kong, Peoples R China
来源：
CHINESE SCIENCE BULLETIN | 2012年 / 57卷 / 18期
基金：
中国国家自然科学基金;
关键词：
polycomb group proteins; carcinogenesis; epigenetic; H3; LYSINE; 27; TARGET GENES; CANCER-CELLS; E-CADHERIN; EZH2; REPRESSION; EXPRESSION; COMPLEX; BMI-1; TUMORIGENESIS;
D O I：
10.1007/s11434-012-5225-9
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In the cell nucleus, DNA is wound around histone proteins, which are then packed together to form chromatin. Histones can be chemically tagged by methyl and acetyl groups. Polycomb group (PcG) proteins attach methyl groups to genes, which block their activity. This is similar to the attachment of methyl groups to gene promoters by DNA methyltransferases (DNMTs). This action is directly linked with tumor initiation and metastasis via the promotion of anti-senescence and anti-apoptosis pathways, and by facilitating epithelial mesenchymal transition (EMT). Cell fate transcriptional factors (CFTFs) and long non-coding RNAs (long ncRNAs) recruit PcG proteins to the promoters of tumor suppressor genes, resulting in epigenetic gene silencing by influencing chromatin structure and DNA accessibility. Thus, PcG proteins are potential diagnostic markers and targets for new chemoprevention and therapeutic strategies.
引用
收藏
页码：2259 / 2264
页数：6
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