Changes in the Cystic Fibrosis Airway Microbiome in Response to CFTR Modulator Therapy

被引：36

作者：

Yi, Buqing ^{[1
]}

Dalpke, Alexander H. ^{[1
]}

Boutin, Sebastien ^{[2
,3
]}

机构：

[1] Tech Univ Dresden, Inst Med Microbiol & Virol, Fac Med, Dresden, Germany

[2] Univ Heidelberg Hosp, Dept Infect Dis Med Microbiol & Hyg, Heidelberg, Germany

[3] Univ Hosp Heidelberg, German Ctr Lung Res DZL, Translat Lung Res Ctr Heidelberg TLRC, Heidelberg, Germany

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2021年 / 11卷

关键词：

cystic fibrosis; CFTR modulator therapy; host– bacteria interaction; Pseudomonas aeruginosa; airway microbiome; PSEUDOMONAS-AERUGINOSA; POTENTIATOR IVACAFTOR; EPIDEMIOLOGY; BACTERIA; MUTATION; DISEASE;

D O I：

10.3389/fcimb.2021.548613

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of CFTR modulator therapies significantly changed the treatment scheme of people with cystic fibrosis. However, CFTR modulator therapy is still a life-long treatment, which is not able to correct the genetic defect and cure the disease. Therefore, it becomes crucial to understand the effects of such modulation of CFTR function on the airway physiology, especially on airway infections and inflammation that are currently the major life-limiting factors in people with cystic fibrosis. In this context, understanding the dynamics of airway microbiome changes in response to modulator therapy plays an essential role in developing strategies for managing airway infections. Whether and how the newly available therapies affect the airway microbiome is still at the beginning of being deciphered. We present here a brief review summarizing the latest information about microbiome alterations in light of modern cystic fibrosis modulator therapy.

引用

页数：7

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