Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance

被引：20

作者：

Ferlito, Alfio ^{[1
]}

Rinaldo, Alessandra ^{[1
]}

Bishop, Justin A. ^{[2
,3
]}

Hunt, Jennifer L. ^{[4
]}

Vander Poorten, Vincent ^{[5
,6
]}

Williams, Michelle D. ^{[7
]}

Triantafyllou, Asterios ^{[8
]}

Devaney, Kenneth O. ^{[9
]}

Gnepp, Douglas R. ^{[10
]}

Kusafuka, Kimihide ^{[11
]}

Halmos, Gyorgy B. ^{[12
]}

Westra, William H. ^{[2
,3
]}

Takes, Robert P. ^{[13
]}

Thompson, Lester D. R. ^{[14
]}

机构：

[1] Univ Udine, Sch Med, Piazzale S Maria della Misericordia, I-33100 Udine, Italy

[2] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

[3] Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA

[4] Univ Arkansas Med Sci, Dept Pathol, Little Rock, AR 72205 USA

[5] Univ Hosp KU Leuven, Otorhinolaryngol Head & Neck Surg, Leuven, Belgium

[6] Univ Hosp KU Leuven, Sect Head & Neck Oncol, Dept Oncol, Leuven, Belgium

[7] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[8] Univ Liverpool, Sch Dent, Oral Pathol, Liverpool L69 3BX, Merseyside, England

[9] Allegiance Hlth, Dept Pathol, Jackson, MI USA

[10] CBLPath, Head & Neck Pathol, Warwick, RI USA

[11] Shizuoka Canc Ctr Hosp & Res Inst, Div Pathol, Shizuoka, Japan

[12] Univ Groningen, Univ Med Ctr Groningen, Dept Otorhinolaryngol Head & Neck Surg, Groningen, Netherlands

[13] Radboud Univ Nijmegen, Med Ctr, Dept Otolaryngol Head & Neck Surg, NL-6525 ED Nijmegen, Netherlands

[14] Woodland Hills Med Ctr, Dept Pathol, Woodland Hills, CA USA

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2016年 / 273卷 / 03期

关键词：

Paraneoplastic syndromes; Neuroendocrine carcinomas; Prognosis; Larynx; Diagnosis; ANTIDIURETIC-HORMONE SECRETION; OAT-CELL CARCINOMA; NECK; HEAD; CANCER; NEOPLASMS; ASSOCIATION;

D O I：

10.1007/s00405-014-3351-5

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Paraneoplastic syndromes are associated with a variety of malignant neoplasms and are systemic and non-metastatic manifestations that develop in a minority of cancer patients. This review examines all published cases of paraneoplastic syndromes associated with neuroendocrine carcinomas of the larynx. There are a total of ten patients reported with paraneoplastic syndromes associated with laryngeal neuroendocrine carcinomas in the literature. Of these, nine died and the tenth is alive with liver metastases. There were five cases of small-cell neuroendocrine carcinoma, four cases of moderately differentiated neuroendocrine carcinoma, and one case of well-differentiated neuroendocrine carcinoma associated with paraneoplastic syndromes. As these syndromes have significant clinical relevance, physicians should be aware of the possible presence of paraneoplastic syndromes in the diagnostic process of patients with neuroendocrine carcinoma of the larynx.

引用

页码：533 / 536

页数：4