We have studied the performance of two multi-pixel Geiger-mode APDs (recently developed by the Centre of Perspective Technologies and Apparatus (CPTA) in Moscow) with 1 x 1 mm(2) and 3 x 3 mm(2) sensitive area as a readout for LSO and LYSO scintillator crystals. Energy and timing spectra were measured using a Na-22 gamma-source. The results of this study allow us to conclude that this photodetector is a very promising candidate for PET applications. (c) 2006 Elsevier B.V. All rights reserved.