Antibacterial phenalenone derivatives from marine-derived fungus Pleosporales sp. HDN1811400

被引：9
作者：
Han, Yaxin [1 ]
Sun, Chunxiao [1 ]
Li, Changlong [1 ]
Zhang, Guojian [1 ,2 ]
Zhu, Tianjiao [1 ]
Li, Dehai [1 ,2 ,3 ]
Che, Qian [1 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China
[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
[3] Pilot Natl Lab Marine Sci & Technol, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Peoples R China
来源：
TETRAHEDRON LETTERS | 2021年 / 68卷
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Phenalenone derivatives; Pleosporales sp; Antibacterial activity; Secondary metabolites; Marine-derived fungi;
D O I：
10.1016/j.tetlet.2021.152938
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three new phenalenone derivatives, namely peniciphenalenins G - L (1-3), together with two related compounds (4 and 5), were isolated from the marine sediment-derived fungus Pleosporales sp. HDN1811400 guided by HPLC-UV profile. Structures including absolute configurations were elucidated by detailed spectroscopic analyses, DFT calculations as well as chemical method. Peniciphenalenin G (1) represents the first example of chlorinated acenaphthenquinone derivative, and compounds 1, 2, 4, and 5 showed broad antibacterial activities with the best MIC value of 6.25 mu M against MRSA. (C) 2021 Elsevier Ltd. All rights reserved.
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页数：4
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