Tropylium-Catalyzed O-H Insertion Reactions of Diazoalkanes with Carboxylic Acids

被引：42

作者：

Empel, Claire ^{[1
]}

Nguyen, Thanh Vinh ^{[2
]}

Koenigs, Rene M. ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

[2] Univ New South Wales, Sch Chem, Sydney, NSW 2052, Australia

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

BOND INSERTION; EFFICIENT;

D O I：

10.1021/acs.orglett.0c04069

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we describe the application of a nonbenzenoid aromatic carbocation, namely tropylium, as an organic Lewis acid catalyst in O-H functionalization reactions of diazoalkanes with benzoic acids. The newly developed protocol is applicable to a wide range of diazoalkane and carboxylic acid substrates with excellent efficiency (43 examples, up to 99% yield).

引用

页码：548 / 553

页数：6