Tropylium-Catalyzed O-H Insertion Reactions of Diazoalkanes with Carboxylic Acids

被引：40
|
作者：
Empel, Claire [1 ]
Nguyen, Thanh Vinh [2 ]
Koenigs, Rene M. [1 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
[2] Univ New South Wales, Sch Chem, Sydney, NSW 2052, Australia
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 02期
基金：
澳大利亚研究理事会;
关键词：
BOND INSERTION; EFFICIENT;
D O I：
10.1021/acs.orglett.0c04069
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we describe the application of a nonbenzenoid aromatic carbocation, namely tropylium, as an organic Lewis acid catalyst in O-H functionalization reactions of diazoalkanes with benzoic acids. The newly developed protocol is applicable to a wide range of diazoalkane and carboxylic acid substrates with excellent efficiency (43 examples, up to 99% yield).
引用
收藏
页码：548 / 553
页数：6
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