Development of atopy and asthma: Candidate environmental influences and important periods of exposure

被引：79

作者：

Peden, DB

机构：

[1] Univ N Carolina, Sch Med, Ctr Environm Med & Lung Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Sch Med, Dept Pediat, Chapel Hill, NC 27599 USA

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 2000年 / 108卷

关键词：

asthma; atopy; immunoglobulin E (IgE); immunoglobulin G (IgG); T-helper cell type 1 (Th1); T-helper cell type 2 (Th2);

D O I：

10.2307/3454539

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Atopy is a major risk factor for the development of asthma. immune processes that lead to the development of antigen-specific IgE are essential to the development of atopy. This review examines the immune processes that are candidate targets for modulation by environmental agents; environmental and lifestyle factors that have been suggested as modulators of the development of atopy; and the impact of known environmental agents on atopic processes in the airway. The most important periods of immune development with regard to expression of atopy are likely during gestation and early childhood. A better understanding of which environmental agents are important, as well as the period of life during which these agents may exert an important effect, is essential to devising rational environmental avoidance strategies for at-risk populations.

引用

页码：475 / 482

页数：8

共 59 条

[1] A polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E [J].