The Role of Hepcidin in Iron Metabolism

被引：446

作者：

Nemeth, Elizabeta ^{[1
]}

Ganz, Tomas ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

ACTA HAEMATOLOGICA | 2009年 / 122卷 / 2-3期

基金：

美国国家卫生研究院;

关键词：

Anemia of inflammation; Bone morphogenetic protein; Hemochromatosis; Hepcidin; Iron-loading anemia; HEREDITARY HEMOCHROMATOSIS PROTEIN; FERROPORTIN; ANEMIA; HYPOFERREMIA; HEMOJUVELIN; EXPRESSION; HORMONE; HFE;

D O I：

10.1159/000243791

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：78 / 86

页数：9

共 25 条

[1] BMP6 orchestrates iron metabolism [J].

Camaschella, Clara .

NATURE GENETICS, 2009, 41 (04) :386-388

[2] The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis [J].

Donovan, A ;

Lima, CA ;

Pinkus, JL ;

Pinkus, GS ;

Zon, LI ;

Robine, S ;

Andrews, NC .

CELL METABOLISM, 2005, 1 (03) :191-200

[3] The molecular basis of hepcidin-resistant hereditary hemochromatosis [J].

Fernandes, Augustine ;

Preza, Gloria C. ;

Phung, Yen ;

De Domenico, Ivana ;

Kaplan, Jerry ;

Ganz, Tomas ;

Nemeth, Elizabeta .

BLOOD, 2009, 114 (02) :437-443

[4] Immunoassay for human serum hepcidin [J].

Ganz, Tomas ;

Olbina, Gordana ;

Girelli, Domenico ;

Nemeth, Elizabeta ;

Westerman, Mark .

BLOOD, 2008, 112 (10) :4292-4297

[5] Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression [J].

Gao, Junwei ;

Chen, Juxing ;

Kramer, Maxwell ;

Tsukamoto, Hidekazu ;

Zhang, An-Sheng ;

Enns, Caroline A. .

CELL METABOLISM, 2009, 9 (03) :217-227

[6] Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing [J].

Goswami, Tapasree ;

Andrews, Nancy C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (39) :28494-28498

[7] Transferrin receptor 2: Evidence for ligand-induced stabilization and redirection to a recycling pathway [J].

Johnson, Martha B. ;

Chen, Juxing ;

Murchison, Nicholas ;

Green, Frank A. ;

Enns, Caroline A. .

MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (03) :743-754

[8] Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4 [J].

Lin, Lan ;

Valore, Erika V. ;

Nemeth, Elizabeta ;

Goodnough, Julia B. ;

Gabatan, Victoria ;

Ganz, Tomas .

BLOOD, 2007, 110 (06) :2182-2189

[9] The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study [J].

Nemeth, E ;

Preza, GC ;

Jung, CL ;

Kaplan, J ;

Waring, AJ ;

Ganz, T .

BLOOD, 2006, 107 (01) :328-333

[10] Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization [J].

Nemeth, E ;

Tuttle, MS ;

Powelson, J ;

Vaughn, MB ;

Donovan, A ;

Ward, DM ;

Ganz, T ;

Kaplan, J .

SCIENCE, 2004, 306 (5704) :2090-2093

← 1 2 3 →