Total synthesis of avermectin B1a revisited

被引：23

作者：

Yamashita, Shuji ^{[1
]}

Hayashi, Daisuke ^{[1
]}

Nakano, Aoi ^{[1
]}

Hayashi, Yujiro ^{[1
]}

Hirama, Masahiro ^{[1
,2
]}

机构：

[1] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 980, Japan

[2] Tohoku Univ, Grad Sch Sci, Res & Analyt Ctr Giant Mol, Sendai, Miyagi 980, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2016年 / 69卷 / 01期

关键词：

ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; EFFICIENT; CONSTRUCTION; IVERMECTIN; ALDEHYDES; ALCOHOLS; ROUTE; DERIVATIVES; CONVENIENT;

D O I：

10.1038/ja.2015.47

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Avermectins were isolated as compounds possessing anthelmintic activity from the culture broth of Streptomycesavermitilis by Omura and co-workers. Owing to their potent anthelmintic and insecticidal activities, as well as their unique pentacyclic architecture, the avermectin family attracted keen interest from synthetic organic chemists. We have recently completed a more efficient and straightforward total synthesis of avermectin B-1a, as compared with previous syntheses.

引用

页码：31 / 50

页数：20

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