Impact of Failed Mitral Clipping on Subsequent Mitral Valve Operations

被引:36
作者
Geidel, Stephan [1 ]
Schmoeckel, Michael [1 ]
机构
[1] Asklepios Kliniken St Georg Eimsbuttel, Abt Herzchirurg, Hamburg, Germany
关键词
PERCUTANEOUS REPAIR; SURGERY; REPLACEMENT; REGURGITATION; TRIAL;
D O I
10.1016/j.athoracsur.2013.07.038
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. This study analyzed the effect of failed percutaneous mitral intervention with the MitraClip device (Abbott Laboratories, Abbott Park, IL) on subsequent mitral valve (MV) operations. Methods. Nineteen patients (74 +/- 9 years) with treatment failure after implantation of 37 MitraClips (mean, 1.9 +/- 0.8; range, 1 to 4) for functional or degenerative MV disease underwent operations a median of 12 days later (range, 0 to 546 days). All patients were studied before and after the operation by clinical investigation and echocardiographic analysis. Intraoperative findings and the effect on the operation were analyzed and are described in detail. Data before clipping and at the time of operation were compared, and the surgical outcome was recorded. Results. There was a significant increase in risk between that at the time of clipping and that at subsequent operations, noted as a rise of the European System for Cardiac Operative Risk Evaluation II from a median 12.74% to 26.87%, respectively (p < 0.0001, Wilcoxon signed rank test). Severe clip implantation-induced tissue damage was found in most patients. Surgical MV repair could be performed in 5 of 6 patients (83%) with a 1-clip implant and in only 3 of 13 patients (23%) when 2 or more clips had been inserted (p = 0.0188, Wilcoxon-Mann-Whitney test). All patients required other associated procedures: closure of an artificial atrial septal defect that was caused by the clipping procedure (100%), tricuspid valve repair (37%), atrial fibrillation ablation operations (37%), coronary artery bypass grafting (16%), and aortic valve replacement (11%). Two early cardiac deaths (< 30 days) occurred. Survival at 1 year was 68%. Conclusions. There is a remarkable impact of failed clipping procedures on MV operations. We observed a severely aggravated cardiac pathology in parallel with a reduced preoperative clinical state compared with the original condition. Moreover, the likelihood of an optimal surgical solution with valve reconstruction was reduced thereafter. However, operations in the critical situation of an unsuccessful mitral clipping procedure should be discussed immediately, because it still seems to be an option compared with conservative therapy. (C) 2014 by The Society of Thoracic Surgeons
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页码:56 / 63
页数:8
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