Cationic amino acid transporter PQLC2 is a potential therapeutic target in gastric cancer

被引:7
作者
Jeung, Yun-Ji [1 ,2 ]
Lee, Kyeong [3 ]
Lee, Hyo Jin [4 ]
Kim, Eunah [5 ]
Son, Myung Jin [5 ,6 ]
Ahn, Jiwon [1 ]
Kim, Han-Gyeul [1 ,6 ]
Kim, Wantae [1 ]
Lee, Ho-Joon [5 ]
Kim, Jin Man [4 ]
Chung, Kyung-Sook [1 ,5 ,6 ]
机构
[1] KRIBB, Biomed Translat Res Ctr, Daejeon, South Korea
[2] Chungnam Natl Univ, Coll Med, Dept Pathol & Med Sci, Daejeon, South Korea
[3] Dongguk Univ Seoul, Coll Pharm, Goyang, South Korea
[4] Chungnam Natl Univ, Coll Med, Dept Internal Med, Daejeon, South Korea
[5] KRIBB, Stem Cell Convergence Res Ctr, Daejeon, South Korea
[6] Korea Univ Sci & Technol UST, KRIBB Sch Biosci, Dept Funct Genom, Daejeon, South Korea
基金
新加坡国家研究基金会;
关键词
gastric cancer; metastasis; PQLC2; therapeutic target; tumor formation; PROTEIN; CHEMOTHERAPY; EXPRESSION; CYSTINOSIS; PATHWAYS; SLC38A9; FUTURE; GENE;
D O I
10.1111/cas.13966
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Tumor cells overexpress amino acid transporters to meet the increased demand for amino acids. PQ loop repeat-containing (PQLC)2 is a cationic amino acid transporter that might be involved in cancer progression. Here, we show that upregulation of PQLC2 is critical to gastric cancer (GC) development in vitro and in vivo. Both PQLC2 mRNA and protein were overexpressed in GC tissues, especially of the diffuse type. Overexpression of PQLC2 promoted cell growth, anchorage independence, and tumor formation in nude mice. This was due to activation of MEK/ERK1/2 and PI3K/AKT signaling. Conversely, PQLC2 knockdown caused growth arrest and cell death of cancer cells and suppressed tumor growth in a mouse xenograft model. These results suggest that targeting PQLC2 is an effective strategy for GC treatment.
引用
收藏
页码:1453 / 1463
页数:11
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