Chemistry of ginkgolides: structure-activity relationship as PAF antagonists

被引：25
|
作者：
Hu, LH [1 ]
Chen, ZL [1 ]
Cheng, XF [1 ]
Xie, YY [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
来源：
PURE AND APPLIED CHEMISTRY | 1999年 / 71卷 / 06期
关键词：
D O I：
10.1351/pac199971061153
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The ginkgolides represent a challenge for the organic chemist owing to their unique cage structure and their high potential biological activity. They were found to be potential PAF antagonists. The results of studies carried out in our laboratory are discussed, leading to conclusions on ginkgolides quantitative structure-activity relationship by using CoMFA and the probable pharmacophore and the interaction fashion between ginkgolides and PAF receptor.
引用
收藏
页码：1153 / 1156
页数：4
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