Chemistry of ginkgolides: structure-activity relationship as PAF antagonists

被引：25

作者：

Hu, LH ^{[1
]}

Chen, ZL ^{[1
]}

Cheng, XF ^{[1
]}

Xie, YY ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China

来源：

PURE AND APPLIED CHEMISTRY | 1999年 / 71卷 / 06期

关键词：

D O I：

10.1351/pac199971061153

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ginkgolides represent a challenge for the organic chemist owing to their unique cage structure and their high potential biological activity. They were found to be potential PAF antagonists. The results of studies carried out in our laboratory are discussed, leading to conclusions on ginkgolides quantitative structure-activity relationship by using CoMFA and the probable pharmacophore and the interaction fashion between ginkgolides and PAF receptor.

引用

页码：1153 / 1156

页数：4

共 13 条

[1] ETHNOPHARMACOLOGY AND THE DEVELOPMENT OF NATURAL PAF ANTAGONISTS AS THERAPEUTIC AGENTS
BRAQUET, P
HOSFORD, D
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 1991, 32 (1-3) : 135 - 139
[2] BUISINE E, 1989, GINKGOLIDES CHEM BIO, V2, P37
[3] Chen JZ, 1998, BIOORG MED CHEM LETT, V8, P1291
[4] Chen Z. L., 1996, CHIN PHARM J, V31, P326
[5] TOTAL SYNTHESIS OF (+/-)-GINKGOLIDE-B
COREY, EJ
KANG, M
DESAI, MC
GHOSH, AK
HOUPIS, JN
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (02) : 649 - 651
[6] SIMPLE ANALOGS OF GINKGOLIDE-B WHICH ARE HIGHLY-ACTIVE ANTAGONISTS OF PLATELET ACTIVATING FACTOR
COREY, EJ
GAVAI, AV
[J]. TETRAHEDRON LETTERS, 1989, 30 (50) : 6959 - 6962
[7] ENANTIOSELECTIVE TOTAL SYNTHESIS OF GINKGOLIDE DERIVATIVES LACKING THE TERT-BUTYL GROUP, AN ESSENTIAL STRUCTURAL SUBUNIT FOR ANTAGONISM OF PLATELET-ACTIVATING-FACTOR
COREY, EJ
RAO, KS
[J]. TETRAHEDRON LETTERS, 1991, 32 (36) : 4623 - 4626
[8] DEFEUDIS FV, 1991, GINKGO BILOBA EXTRAC, P97
[9] GINKGO-BILOBA
KLEIJNEN, J
KNIPSCHILD, P
[J]. LANCET, 1992, 340 (8828) : 1136 - 1139
[10] A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia
LeBars, PL
Katz, MM
Berman, N
Itil, TM
Freedman, AM
Schatzberg, AF
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (16): : 1327 - 1332

← 1 2 →