Studies on Insecticidal Activities and Action Mechanism of Novel Benzoylphenylurea Candidate NK-17

被引：13

作者：

Li, Yongqiang ^{[1
,2
]}

Qin, Yaoguo ^{[1
]}

Yang, Na ^{[2
]}

Sun, Yufeng ^{[1
]}

Yang, Xinling ^{[1
]}

Sun, Ranfeng ^{[2
]}

Wang, Qingmin ^{[2
]}

Ling, Yun ^{[1
]}

机构：

[1] China Agr Univ, Key Lab Pesticide Chem & Applicat, MOA, Dept Appl Chem,Coll Sci, Beijing 100094, Peoples R China

[2] Nankai Univ, Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

PLOS ONE | 2013年 / 8卷 / 06期

基金：

中国国家自然科学基金;

关键词：

SULFONYLUREA RECEPTOR; GROWTH-REGULATORS; INHIBITION; DESIGN; DIFLUBENZURON; BIOACTIVITY; PUPAE; MODE;

D O I：

10.1371/journal.pone.0066251

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Insecticidal activity of NK-17 was evaluated both in laboratory and in field. It was found that the toxicity of NK-17 against S. exigua was 1.93 times and 2.69 times those of hexaflumuron and chlorfluazuron respectively, and the toxicity of NK-17 against P. xylostella was 1.36 times and 1.90 times those of hexaflumuron and chlorfluazuron respectively, and the toxicity of NK-17 against M. separate was 18.24 times those of hexaflumuron in laboratory, and 5% NK-17 EC at 60 g a.i ha(-1) can control S. exigua and P. xylostella with the best control efficiency of about 89% and over 88% respectively in Changsha and Tianjin in field. The insecticidal mechanism of NK-17 was explored for the first time by utilizing the fluorescence polarization method. NK-17 could bind to sulfonylurea receptor (SUR) of B. germanica with stronger affinity comparing to diflubenzuron and glibenclamide, which suggested that NK-17 may also act on the site of SUR to inhibit the chitin synthesis in insect body and the result can well explain that NK-17 exhibited stronger toxicity against B. germanica than diflubenzuron and glibenclamide in vivo.

引用

页数：13

共 34 条

[1]

ABBOTT W.S., 1925, J ECON ENTOMOL, V18, P265

[2] Significance of the sulfonylurea receptor (SUR) as the target of diflubenzuron in chitin synthesis inhibition in Drosophila melanogaster and Blattella germanica [J].