Successful treatment of severe thrombocytopenia with romiplostim in a pregnant patient with systemic lupus erythematosus

被引：47

作者：

Alkaabi, J. K. ^{[1
]}

Alkindi, S. ^{[2
]}

Al Riyami, N. ^{[3
]}

Zia, F. ^{[2
]}

Balla, L. M. A. ^{[1
]}

Balla, S. M. ^{[3
]}

机构：

[1] Sultan Qaboos Univ Hosp, Dept Med, Rheumatol Unit, Muscat 123, Oman

[2] Sultan Qaboos Univ Hosp, Dept Haematol, Muscat 123, Oman

[3] Sultan Qaboos Univ Hosp, Dept Obstet & Gynecol, Muscat 123, Oman

来源：

LUPUS | 2012年 / 21卷 / 14期

关键词：

Antiphospholipid syndrome; Evans syndrome; rituximab; eltrombopag; romiplostim; systemic lupus erythematosus; thrombocytopenia; EFFICACY;

D O I：

10.1177/0961203312463621

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We present a case of a pregnant woman at 27 weeks of gestation with systemic lupus erythematosus who developed severe thrombocytopenia presenting with melena, epistaxis, gum bleeding and frank hematuria. She was resistant to most treatment modalities, including steroids, intravenous immunoglobulins (IVIG), rituximab, IV cyclophosphamide and eltrombopag. She responded to romiplostim with normalization of her platelet count, which enabled her to be delivered safely at 34 weeks of gestation. Lupus (2012) 21, 1571-1574.

引用

页码：1571 / 1574

页数：4

共 50 条

[1] SEVERE THROMBOCYTOPENIA IN A PREGNANT WOMAN WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
BOIX, MM
GONZALEZ, GO
GARCIATEVAR, A
LAZARO, AM
MEDICINA CLINICA, 1986, 87 (10): : 435 - 435
[2] Successful treatment of refractory thrombocytopenia with mycophenolate mofetil in a patient with systemic lupus erythematosus
Chang, HK
JOURNAL OF KOREAN MEDICAL SCIENCE, 2005, 20 (05) : 883 - 885
[3] Successful Treatment with Rituximab in a Patient with Castleman’s Disease Complicated by Systemic Lupus Erythematosus and Severe Autoimmune Thrombocytopenia
Zhang Lu
Jiao Li
Wang Shu-Jie
中华医学杂志英文版, 2015, 128 (18) : 2551 - 2552
[4] The treatment of systemic lupus erythematosus in the pregnant patient
Saavedra-Salinas, M. A.
Carrillo-Vazquez, S. M.
Jara-Quezada, L. J.
Miranda-Limon, J. M.
REUMATOLOGIA CLINICA, 2005, 1 : S46 - S51
[5] Successful Treatment with Rituximab in a Patient with Castleman's Disease Complicated by Systemic Lupus Erythematosus and Severe Autoimmune Thrombocytopenia
Zhang, Lu
Jiao, Li
Wang, Shu-Jie
CHINESE MEDICAL JOURNAL, 2015, 128 (18) : 2551 - 2552
[6] SEVERE THROMBOCYTOPENIA IN SYSTEMIC LUPUS ERYTHEMATOSUS: TREATMENT WITH HYDROXYCHLOROQUINE ALONE
Azharuddin, M.
Brawer, A. E.
JOURNAL OF INVESTIGATIVE MEDICINE, 2017, 65 (04) : 876 - 877
[7] EFFECTIVENESS OF ROMIPLOSTIM IN REFRACTORY IMMUNE THROMBOCYTOPENIA ASSOCIATED WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Teerakanok, J.
Adiga, A.
Nugent, K.
JOURNAL OF INVESTIGATIVE MEDICINE, 2017, 65 (02) : 575 - 575
[8] Correction of severe leukocytopenia and thrombocytopenia in systemic lupus erythematosus by treatment with dapsone
Nishina, M
Saito, E
Kinoshita, M
JOURNAL OF RHEUMATOLOGY, 1997, 24 (04) : 811 - 812
[9] Successful treatment of amegakaryocytic thrombocytopenia with anti-CD20 antibody (rituximab) in a patient with systemic lupus erythematosus
Fukushima, T.
Dong, L.
Sakai, T.
Sawaki, T.
Miki, M.
Tanaka, M.
Masaki, Y.
Hirose, Y.
Kuwana, M.
Umehara, H.
LUPUS, 2008, 17 (03) : 210 - 214
[10] Treatment of severe immune thrombocytopenia associated with systemic lupus erythematosus:: 59 cases
Arnal, C
Piette, JC
Léone, J
Taillan, B
Hachulla, E
Roudot-Thoraval, F
Papo, T
Schaeffer, A
Bierling, P
Godeau, B
JOURNAL OF RHEUMATOLOGY, 2002, 29 (01) : 75 - 83

← 1 2 3 4 5 →