Glycoprotein Disease Markers and Single Protein-omics

被引：53
作者：
Chandler, Kevin [1 ]
Goldman, Radoslav [1 ,2 ]
机构：
[1] Georgetown Univ, Dept Biochem & Mol & Cellular Biol, Washington, DC 20057 USA
[2] Georgetown Univ, Dept Oncol, Washington, DC 20057 USA
来源：
MOLECULAR & CELLULAR PROTEOMICS | 2013年 / 12卷 / 04期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
MONOCLONAL-ANTIBODY; BREAST-CANCER; OVARIAN-CANCER; HEPATOCELLULAR-CARCINOMA; MASS-SPECTROMETRY; ALPHA-FETOPROTEIN; CLINICAL UTILITY; CA-19-9; ANTIGEN; HUMAN-COLON; GLYCAN;
D O I：
10.1074/mcp.R112.026930
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Glycoproteins are well represented among biomarkers for inflammatory and cancer diseases. Secreted and membrane-associated glycoproteins make excellent targets for noninvasive detection. In this review, we discuss clinically applicable markers of cancer diseases and methods for their analysis. High throughput discovery continues to supply marker candidates with unusual glycan structures, altered glycoprotein abundance, or distribution of site-specific glycoforms. Improved analytical methods are needed to unlock the potential of these discoveries in validated clinical assays. A new generation of targeted quantitative assays is expected to advance the use of glycoproteins in early detection of diseases, molecular disease classification, and monitoring of therapeutic interventions. Molecular & Cellular Proteomics 12: 10.1074/mcp.R112.026930, 836-845, 2013.
引用
收藏
页码：836 / 845
页数：10
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