Occult hepatitis B virus infection among injecting drug users in the Central-West Region of Brazil

被引：17
|
作者：
Dias de Matos, Marcia Alves [1 ]
Ferreira, Renata Carneiro [1 ]
Rodrigues, Fabiana Perez [2 ]
Marinho, Tamiris Augusto [1 ]
Rodrigues Lopes, Carmen Luci [2 ]
Magalhaes Novais, Antonia Carlos [4 ]
Coimbra Motta-Castro, Ana Rita [3 ]
Teles, Sheila Araujo [2 ]
Dutra Souto, Francisco Jose [4 ]
Bringel Martins, Regina Maria [1 ]
机构：
[1] Univ Fed Goias, Inst Patol Trop & Saude Publ, Goiania, Go, Brazil
[2] Univ Fed Goias, Fac Enfermagem, Goiania, Go, Brazil
[3] Univ Fed Mato Grosso do Sul, Dept Farm Bioquim, Campo Grande, MS, Brazil
[4] Univ Fed Mato Grosso, Fac Ciencias Med, Cuiaba, MT, Brazil
来源：
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2013年 / 108卷 / 03期
关键词：
hepatitis B virus; occult infection; genotypes; GENETIC DIVERSITY; VIRAL-HEPATITIS; HIGH PREVALENCE; RISK-FACTORS; GENOTYPES; EPIDEMIOLOGY;
D O I：
10.1590/S0074-02762013000300019
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The prevalence of occult hepatitis B virus (HBV) infection was investigated in 149 hepatitis B surface antigen (HBsAg) negative injecting drug users (IDUs) in the Central-West Region of Brazil. Of these individuals, 19 were positive for HBV DNA, resulting in an occult HBV infection prevalence of 12.7% (19/149); six of these 19 individuals had anti-HBV core and/or anti-HBV surface antibodies and 13 were negative for HBV markers. All IDUs with occult hepatitis B reported sexual and/or parenteral risk behaviours. All HBV DNA-positive samples were successfully genotyped. Genotype D was the most common (17/19), followed by genotype A (2/19). These findings reveal a high prevalence of occult HBV infection and the predominance of genotype D among IDUs in Brazil's Central-West Region.
引用
收藏
页码：386 / 389
页数：4
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