[2] Univ Fed Goias, Fac Enfermagem, Goiania, Go, Brazil
[3] Univ Fed Mato Grosso do Sul, Dept Farm Bioquim, Campo Grande, MS, Brazil
[4] Univ Fed Mato Grosso, Fac Ciencias Med, Cuiaba, MT, Brazil
来源:
MEMORIAS DO INSTITUTO OSWALDO CRUZ
|
2013年
/
108卷
/
03期
关键词:
hepatitis B virus;
occult infection;
genotypes;
GENETIC DIVERSITY;
VIRAL-HEPATITIS;
HIGH PREVALENCE;
RISK-FACTORS;
GENOTYPES;
EPIDEMIOLOGY;
D O I:
10.1590/S0074-02762013000300019
中图分类号:
R38 [医学寄生虫学];
Q [生物科学];
学科分类号:
07 ;
0710 ;
09 ;
100103 ;
摘要:
The prevalence of occult hepatitis B virus (HBV) infection was investigated in 149 hepatitis B surface antigen (HBsAg) negative injecting drug users (IDUs) in the Central-West Region of Brazil. Of these individuals, 19 were positive for HBV DNA, resulting in an occult HBV infection prevalence of 12.7% (19/149); six of these 19 individuals had anti-HBV core and/or anti-HBV surface antibodies and 13 were negative for HBV markers. All IDUs with occult hepatitis B reported sexual and/or parenteral risk behaviours. All HBV DNA-positive samples were successfully genotyped. Genotype D was the most common (17/19), followed by genotype A (2/19). These findings reveal a high prevalence of occult HBV infection and the predominance of genotype D among IDUs in Brazil's Central-West Region.