Pyrrolidine-HOBt: an oxytriazole catalyst for the enantioselective Michael addition of cyclohexanone to nitroolefins in water

被引：13

作者：

Kumar, Togapur Pavan ^{[1
,2
]}

Prasad, Sthanikam Siva ^{[1
,3
]}

Haribabu, Kothapalli ^{[1
]}

Kumar, Veerjala Naveen ^{[1
]}

Reddy, Cirandur Suresh ^{[3
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Div Nat Prod Chem, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, CSIR, Acad Sci & Innovat Res AcSIR, Hyderabad 500007, Andhra Pradesh, India

[3] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 2016年 / 27卷 / 22-23期

关键词：

ASYMMETRIC ALDOL REACTIONS; CONJUGATE ADDITION; ALPHA; ALPHA-DISUBSTITUTED ALDEHYDES; BETA-NITROSTYRENES; NITRO-MICHAEL; BIFUNCTIONAL ORGANOCATALYSTS; EFFICIENT ORGANOCATALYSTS; RECYCLABLE ORGANOCATALYST; CYCLIC-KETONES; IONIC LIQUIDS;

D O I：

10.1016/j.tetasy.2016.08.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new analogue of the proline derived organocatalyst 'pyrrolidine-HOBt' has been designed and synthesized from L-prolinol and hydroxybenzotriazole (HOBt) employing a simple reaction protocol. The catalyst was found to be effective in promoting the asymmetric Michael addition of cyclohexanone to nitroolefins using water as the reaction medium. The reaction products gamma-nitrocarbonyls are obtained in good yields and stereoselectivities. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1133 / 1138

页数：6

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