Anti-oxidative and Anti-inflammatory Effects of Flavonoids from the Silk of Zea mays Linn

被引：6

作者：

Oh, M. H. ^{[1
]}

Choe, K. I. ^{[1
]}

Cho, S. H. ^{[1
]}

Jeong, M. S. ^{[1
]}

Myung, S. C. ^{[2
]}

Seo, S. J. ^{[2
]}

Choi, S. E. ^{[3
]}

Lee, M. W. ^{[1
]}

机构：

[1] Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea

[2] Chung Ang Univ, Coll Med, Seoul 156756, South Korea

[3] Nambu Univ, Dept Cosmetol Sci, Gwangju City 506706, South Korea

来源：

ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 08期

关键词：

Zea mays Linn; Flavonoid; Anti-oxidative; Anti-inflammatory; Inducible nitric oxide synthase; Cyclooxygenase-2; NITRIC-OXIDE SYNTHASE; CYCLOOXYGENASE; GLYCOSIDES; STYLE;

D O I：

10.14233/ajchem.2013.13943

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Activity-guided isolation of the silk of Zea mays Linn (ZMS) yielded three flavonoids, chrysoeriol-6-C-beta-boivinopyranosyl-7-O-beta-glucopyranoside (1), chrysoeriol (2) and luteolin (3). Anti-oxidative activity was measured using the 2,2-diphenyl-1-picryl-hydrazyl and superoxide dismutase-like superoxide anion (generated by xanthine oxidase/hypoxanthine) scavenging assays. Anti-inflammatory activity was confined by quantifying the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated HaCaT cells using western blotting and real-time polymerase chain reaction. The results showed that luteolin 3 exhibited potent 2,2-diphenyl-1-picryl-hydrazyl (IC50 = 18.31 +/- 1.29 mu M) and superoxide dismutase-like superoxide anion scavenging activity (IC50 = 1.47 +/- 0.14 mu M) and dose-dependently inhibited the protein expression of inducible nitric oxide synthase and cyclooxygenase-2 as well as their mRNA levels.

引用

页码：4293 / 4297

页数：5

共 24 条

[21] COINDUCTION OF NITRIC-OXIDE SYNTHASE AND CYCLOOXYGENASE - INTERACTIONS BETWEEN NITRIC-OXIDE AND PROSTANOIDS [J].