Application of enhanced recovery after surgery in total knee arthroplasty in patients with haemophilia A: A pilot study

Aim To identify the effect of enhanced recovery after surgery (ERAS) and rapid rehabilitation concepts on the outcomes of patients with haemophilia A undergoing total knee arthroplasty. Design Randomized controlled trial. Methods The primary endpoint was postoperative hospital stay. The secondary endpoints were pain scores, joint function scores, haemoglobin levels at 3 and 7 days after surgery and satisfaction with hospitalization. Results Thirty-two patients were enrolled. Compared with the routine nursing group, the ERAS group showed shorter postoperative hospital stay (14.2SD0.8 vs. 16.6 +/- 1.3 days,p < .001), smaller amounts of blood transfusion (924SD317 vs. 1,263SD449 ml,p = .020) and coagulation factors (37,325SD5,996 vs. 48,475SD8,019 U,p < .001), lower pain scores at 3 (3.3SD0.7 vs. 4.3SD0.7,p = .002) and 7 (2.3 SD 0.7 vs. 2.8 +/- 0.5,p = .015) days, lower hospital for special surgery knee scores at 3 (59.9SD7.8 vs. 53.6 SD 5.9,p = .016) and 7 (77.9SD6.9 vs. 71.1 +/- 7.1,p = .009) days and higher satisfaction with hospitalization (94.3SD1.4 vs. 92.7SD1.6,p = .004).