Dynamics of Blood Pressure Elevation and Endothelial Dysfunction in SHR Rats During the Development of Arterial Hypertension

被引：17

作者：

Anishchenko, A. M. ^{[1
]}

Aliev, O. I. ^{[1
,2
]}

Sidekhmenova, A. V. ^{[1
]}

Shamanaev, A. Yu. ^{[1
]}

Plotnikov, M. B. ^{[1
,2
]}

机构：

[1] ED Goldberg Res Inst Pharmacol & Regenerat Med, Lab Pharmacol Blood Circulat, Tomsk, Russia

[2] Natl Res Tomsk State Univ, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 159卷 / 05期

基金：

俄罗斯科学基金会;

关键词：

arterial hypertension; blood pressure; SHR rats; Wistar-Kyoto rats; endothelial dysfunction; NITRIC-OXIDE SYNTHASE; NUMBER; VOLUME;

D O I：

10.1007/s10517-015-3020-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The dynamics of systolic and diastolic BP and vasodilatory activity of the endothelium in SHR and Wistar-Kyoto rats was studied from the 5th to the 12th week of life. Systolic and diastolic BP did not differ in 5-week-old SHR and Wistar-Kyoto rats. After the 6th week of life, two stages of arterial hypertension development were observed in SHR. Stage 1 (weeks 6-8) was characterized by a significant increase in systolic and diastolic BP that exceeded the corresponding parameters in Wistar-Kyoto rats by 26-32%. Vasodilatory activity of the endothelium was similar in rats of both strains at the age of 5-7 weeks. Stage 2 (weeks 9-12) in SHR rats was characterized by further increase in systolic and diastolic BP that exceeded the corresponding parameters in Wistar-Kyoto rats by 54-89%. The increase in BP during this period was accompanied by a significant decrease in endothelium-dependent relaxation (by 14-16% compared to that in Wistar-Kyoto rats of the same age).

引用

页码：591 / 593

页数：3

共 15 条

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