An Interglomerular Circuit Gates Glomerular Output and Implements Gain Control in the Mouse Olfactory Bulb

被引:119
作者
Banerjee, Arkarup [1 ,2 ]
Marbach, Fred [1 ,2 ]
Anselmi, Francesca [1 ]
Koh, Matthew S. [1 ,2 ]
Davis, Martin B. [1 ]
da Silva, Pedro Garcia [1 ,3 ]
Delevich, Kristen [1 ,2 ]
Oyibo, Hassana K. [1 ,2 ]
Gupta, Priyanka [1 ,4 ]
Li, Bo [1 ,2 ]
Albeanu, Dinu F. [1 ,2 ]
机构
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
[2] Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
[3] Champalimaud Ctr Unknown, Champalimaud Neurosci Programme, P-1400038 Lisbon, Portugal
[4] Tata Inst Fundamental Res, Natl Ctr Biol Sci, Bangalore 560065, Karnataka, India
关键词
EXTERNAL TUFTED CELLS; MITRAL CELLS; ODOR MAP; INHIBITION; INTERNEURONS; NEURONS; MECHANISMS; EXPRESSION; RESPONSES; NORMALIZATION;
D O I
10.1016/j.neuron.2015.06.019
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Odors elicit distributed activation of glomeruli in the olfactory bulb (OB). Crosstalk between co-active glomeruli has been proposed to perform a variety of computations, facilitating efficient extraction of sensory information by the cortex. Dopaminergic/GABAergic cells in the OB, which can be identified by their expression of the dopamine transporter (DAT), provide the earliest opportunity for such crosstalk. Here we show in mice that DAT+ cells carry concentration-dependent odor signals and broadcast focal glomerular inputs throughout the OB to cause suppression of mitral/tufted (M/T) cell firing, an effect that is mediated by the external tufted (ET) cells coupled to DAT+ cells via chemical and electrical synapses. We find that DAT+ cells implement gain control and decorrelate odor representations in the M/T cell population. Our results further indicate that ET cells are gatekeepers of glomerular output and prime determinants of M/T responsiveness.
引用
收藏
页码:193 / 207
页数:15
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