Emerging role of microRNAs in lipid metabolism

被引：137
|
作者：
Yang, Zhihong [1 ,2 ,3 ]
Cappello, Tyler [1 ,2 ]
Wang, Li [1 ,2 ,3 ,4 ]
机构：
[1] Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT 06269 USA
[2] Univ Connecticut, Inst Syst Genom, Storrs, CT 06269 USA
[3] Vet Affairs Connecticut Healthcare Syst, West Haven, CT 06516 USA
[4] Yale Univ, Dept Internal Med, Sect Digest Dis, New Haven, CT 06520 USA
来源：
ACTA PHARMACEUTICA SINICA B | 2015年 / 5卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Lipid merabolism; microRNAS; Nuclear receptors; FARNESOID X RECEPTOR; NUCLEAR RECEPTORS; GENE-EXPRESSION; PPAR-GAMMA; CHOLESTEROL HOMEOSTASIS; HEPATIC STEATOSIS; DOWN-REGULATION; LIVER-DISEASE; CANCER-CELLS; IN-VIVO;
D O I：
10.1016/j.apsb.2015.01.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
microRNAs (miRNAs or miRs) are small non-coding RNAs that are involved in post-transcriptional regulation of their target genes in a sequence-specific manner. Emerging evidence demonstrates that miRNAs are critical regulators of lipid synthesis, fatty acid oxidation and lipoprotein formation and secretion. Dysregulation of miRNAs disrupts gene regulatory network, leading to metabolic syndrome and its related diseases. In this review, we introduced epigenetic and transcriptional regulation of miRNAs expression. We emphasized on several representative miRNAs that are functionally involved into lipid metabolism, including miR-33133*, miR122, miR27a/b, miR378/378*, miR-34a and miR-21. Understanding the function of miRNAs in lipid homeostasis may provide potential therapeutic strategies for fatty liver disease. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. All rights reserved.
引用
收藏
页码：145 / 150
页数：6
相关论文
共 50 条
  • [41] Emerging role of microRNAs in ischemic stroke with comorbidities
    Qian, Yu
    Chopp, Michael
    Chen, Jieli
    EXPERIMENTAL NEUROLOGY, 2020, 331
  • [42] The Role of microRNAs in Inflammation
    Das, Kaushik
    Rao, L. Vijaya Mohan
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (24)
  • [43] The role of microRNAs in hepatocyte metabolism and hepatitis B virus replication
    Deng, Wanyu
    Lu, Mengji
    VIROLOGICA SINICA, 2016, 31 (06) : 472 - 479
  • [44] Regulation of Glucose Metabolism in Hepatocarcinogenesis by MicroRNAs
    Reyes, Ryan K.
    Motiwala, Tasneem
    Jacob, Samson T.
    GENE EXPRESSION, 2014, 16 (02): : 85 - 92
  • [45] The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism
    Hunt, Mary C.
    Siponen, Marina I.
    Alexson, Stefan E. H.
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2012, 1822 (09): : 1397 - 1410
  • [46] Transcriptional Regulation of Human and Rat Hepatic Lipid Metabolism by the Grapefruit Flavonoid Naringenin: Role of PPARα, PPARγ and LXRα
    Goldwasser, Jonathan
    Cohen, Pazit Y.
    Yang, Eric
    Balaguer, Patrick
    Yarmush, Martin L.
    Nahmias, Yaakov
    PLOS ONE, 2010, 5 (08):
  • [47] The emerging role of metabolism in fibrosis
    Henderson, John
    O'Reilly, Steven
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2021, 32 (08): : 639 - 653
  • [48] MicroRNAs in Leukemias: Emerging Diagnostic Tools and Therapeutic Targets
    Mian, Yousaf A.
    Zeleznik-Le, Nancy J.
    CURRENT DRUG TARGETS, 2010, 11 (07) : 801 - 811
  • [49] The interplay between viruses & host microRNAs in cancer - An emerging role for HIV in oncogenesis
    Mapekula, L.
    Ramorola, B. R.
    Hoosen, T. Goolam
    Mowla, S.
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2019, 137 : 108 - 114
  • [50] Emerging role of microRNAs in regulating macrophage activation and polarization in immune response and inflammation
    Wu, Xiao-qin
    Dai, Yao
    Yang, Yang
    Huang, Cheng
    Meng, Xiao-ming
    Wu, Bao-ming
    Li, Jun
    IMMUNOLOGY, 2016, 148 (03) : 237 - 248
12345