Emerging role of microRNAs in lipid metabolism

被引：142

作者：

Yang, Zhihong ^{[1
,2
,3
]}

Cappello, Tyler ^{[1
,2
]}

Wang, Li ^{[1
,2
,3
,4
]}

机构：

[1] Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT 06269 USA

[2] Univ Connecticut, Inst Syst Genom, Storrs, CT 06269 USA

[3] Vet Affairs Connecticut Healthcare Syst, West Haven, CT 06516 USA

[4] Yale Univ, Dept Internal Med, Sect Digest Dis, New Haven, CT 06520 USA

来源：

ACTA PHARMACEUTICA SINICA B | 2015年 / 5卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Lipid merabolism; microRNAS; Nuclear receptors; FARNESOID X RECEPTOR; NUCLEAR RECEPTORS; GENE-EXPRESSION; PPAR-GAMMA; CHOLESTEROL HOMEOSTASIS; HEPATIC STEATOSIS; DOWN-REGULATION; LIVER-DISEASE; CANCER-CELLS; IN-VIVO;

D O I：

10.1016/j.apsb.2015.01.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

microRNAs (miRNAs or miRs) are small non-coding RNAs that are involved in post-transcriptional regulation of their target genes in a sequence-specific manner. Emerging evidence demonstrates that miRNAs are critical regulators of lipid synthesis, fatty acid oxidation and lipoprotein formation and secretion. Dysregulation of miRNAs disrupts gene regulatory network, leading to metabolic syndrome and its related diseases. In this review, we introduced epigenetic and transcriptional regulation of miRNAs expression. We emphasized on several representative miRNAs that are functionally involved into lipid metabolism, including miR-33133*, miR122, miR27a/b, miR378/378*, miR-34a and miR-21. Understanding the function of miRNAs in lipid homeostasis may provide potential therapeutic strategies for fatty liver disease. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：145 / 150

页数：6

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