Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification

被引：21

作者：

Yamashita, Kyoko ^{[1
]}

Kohashi, Kenichi ^{[2
]}

Yamada, Yuichi ^{[2
]}

Ishii, Takeaki ^{[2
]}

Nishida, Yoshihiro ^{[3
]}

Urakawa, Hiroshi ^{[3
]}

Ito, Ichiro ^{[4
]}

Takahashi, Mitsuru ^{[5
]}

Inoue, Takeshi ^{[6
]}

Ito, Masafumi ^{[7
]}

Ohara, Yuuki ^{[1
]}

Oda, Yoshinao ^{[2
]}

Toyokuni, Shinya ^{[1
]}

机构：

[1] Nagoya Univ, Dept Pathol & Biol Responses, Grad Sch Med, Nagoya, Aichi, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Fukuoka, Japan

[3] Nagoya Univ, Dept Orthoped Surg, Grad Sch & Sch Med, Nagoya, Aichi, Japan

[4] Shizuoka Canc Ctr Hosp, Dept Pathol, Shizuoka, Japan

[5] Shizuoka Canc Ctr Hosp, Div Orthopaed Oncol, Shizuoka, Japan

[6] Osaka City Gen Hosp, Dept Pathol, Osaka, Japan

[7] Japanese Red Cross Nagoya First Hosp, Dept Pathol, Nagoya, Aichi, Japan

来源：

HISTOPATHOLOGY | 2018年 / 72卷 / 05期

关键词：

dedifferentiated liposarcoma; MDM2; amplification; osteogenic differentiation; METAPLASTIC BONE-FORMATION; MENINGOTHELIAL-LIKE WHORLS; SOFT-TISSUE; RETROPERITONEUM; COMPONENT; TUMORS; GRADE; MDM2;

D O I：

10.1111/his.13421

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

AimsOssification is found occasionally in dedifferentiated liposarcoma (DDLPS). The aims of this study were to elucidate whether the formed bone tissue is usually produced by tumour cells or by reactive non-neoplastic cells, and to reveal the clinicopathological characteristics of DDLPS with ossification. Methods and resultsWe examined 36 cases of ossified DDLPS by comparing them to 31 cases of non-ossified DDLPS. MDM2 amplification was confirmed in osteocytes and/or osteoblastic cells in all but one ossified DDLPS cases (27 of 28) using fluorescence in-situ hybridisation, although the morphological impression of ossification appeared to be mainly metaplastic (27 of 36) or high-grade osteosarcoma-like (six of 36). The bone tissue was often formed predominantly at the periphery of the DDLPS area near the well-differentiated liposarcoma component (18 of 36), and an organised structure such as bone marrow-like differentiation was not uncommon (12 of 36). According to a modified French Federation Nationale des Centers de Lutte Contre le Cancer (FNCLCC) grading system, ossified DDLPS tended to be lower grade than non-ossified DDLPS (mean grade: 1.88 and 2.15, respectively). Ossification in DDLPS was associated significantly with shorter local recurrence-free survival by multivariate analysis (P=0.02347), but metaplastic-appearing ossification tended to be associated with longer overall survival (P=0.1400). ConclusionsThe bone tissue formed in DDLPS was mainly neoplastic regardless of its morphology and maturity, which highlighted the osteogenic differentiation of the tumour cells. DDLPS patients with osteogenic differentiation tended to suffer from earlier local recurrences, which did not necessarily lead to poor life outcomes.

引用

页码：729 / 738

页数：10

共 24 条

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