Bilobalide Protects Pheochromocytoma Cell from Oxygen-Glucose Deprivation/Reperfusion Induced Injury via Activating Wnt1/Beta Catenin Pathway

被引：0

作者：

Yu, X. ^{[1
]}

Hou, Jie ^{[2
]}

Qian, Kai ^{[1
]}

Xu, Chunxiang ^{[1
]}

Chen, Yanguo ^{[1
]}

Guo, Z. ^{[2
]}

Wu, Xiaohong ^{[1
]}

Xiao, G. ^{[2
]}

机构：

[1] Dongtai Peoples Hosp, Dept Neurol, Dongtai 224200, Jiangsu, Peoples R China

[2] Soochow Univ, Affiliated Hosp 2, Suzhou Clin Res Ctr Neurol Dis, Dept Neurol, Suzhou 215004, Jiangsu, Peoples R China

来源：

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2022年 / 84卷 / 05期

关键词：

Bilobalide; ischemia; cell damage; apoptosis; neuroprotective agents;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To explore the protective effect of bilobalide on the pheochromocytoma cell injury induced by oxygen-glucose deprivation/reperfusion in vitro. To simulate ischemia-reperfusion condition, the pheochromocytoma cell injury was induced by oxygen-glucose deprivation/reperfusion in vitro. The cells were divided into control, oxygen-glucose deprivation/reperfusion and oxygen-glucose deprivation/ reperfusion+bilobalide groups. The cell viability, proliferative capacity, malondialdehyde level, superoxide dismutase level, apoptosis, Wnt1 protein level and nuclear beta-catenin protein level were assayed. Compared with control group, the cell viability, proliferative capacity, superoxide dismutase level, Wnt1 protein level and nuclear beta-catenin protein level decreased in the oxygen-glucose deprivation/ reperfusion group, malondialdehyde level and the percentage of apoptotic cells increased in the oxygen -glucose deprivation/reperfusion group, while the cells were treated with bilobalide in the oxygen-glucose deprivation/reperfusion+bilobalide group, all the above-mentioned observation indicators recovered to a certain extent, but still did not reach the level of the control group. Bilobalide protects pheochromocytoma cell from oxygen-glucose deprivation/reperfusion induced injury in vitro through inhibiting oxidative stress via activating Wnt1/beta-catenin pathway.

引用

页码：1323 / 1327

页数：5

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