Janus-Faced PIDD: A Sensor for DNA Damage-Induced Cell Death or Survival?

被引：5

作者：

McCoy, Francis ^{[1
]}

Eckard, Laura ^{[1
]}

Nutt, Leta K. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Biochem, Memphis, TN 38105 USA

来源：

MOLECULAR CELL | 2012年 / 47卷 / 05期

关键词：

CASPASE-2; ACTIVATION; PIDDOSOME; COMPLEX; PHOSPHORYLATION; APOPTOSIS;

D O I：

10.1016/j.molcel.2012.08.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of Molecular Cell, an activator of the PIDDosome (a complex comprising of PIDD, RAIDD, and caspase-2) is described in experiments detailing endogenous PIDDosome assembly and caspase-2 function after DNA damage in the presence of Chk1 suppression (Ando et al., 2012).

引用

页码：667 / 668

页数：2

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