Advances in Magnetic Nanoparticles for Biomedical Applications

被引:525
作者
Cardoso, Vanessa Fernandes [1 ,2 ]
Francesko, Antonio [1 ]
Ribeiro, Clarisse [1 ,3 ]
Banobre-Lopez, Manuel [4 ]
Martins, Pedro [1 ]
Lanceros-Mendez, Senentxu [5 ,6 ]
机构
[1] Univ Minho, Ctr Fis, P-4710057 Braga, Portugal
[2] Univ Minho, MEMS Microelectromech Syst Res Unit, P-4800058 Guimaraes, Portugal
[3] Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal
[4] INL Int Iberian Nanotechnol Lab, P-4715 Braga, Portugal
[5] BCMaterials, Parque Cient & Tecnol Bizkaia, Derio 48160, Spain
[6] Basque Fdn Sci, Ikerbasque, Bilbao 48013, Spain
关键词
drug release; hyperthermia; lab-on-chip; magnetic nanoparticles; tissue engineering; IRON-OXIDE NANOPARTICLES; ON-A-CHIP; CIRCULATING TUMOR-CELLS; MESOPOROUS SILICA NANOPARTICLES; TRIGGERED DRUG-RELEASE; SUPERPARAMAGNETIC NANOPARTICLES; FE3O4; NANOPARTICLES; MULTIFUNCTIONAL NANOPARTICLES; OSTEOGENIC DIFFERENTIATION; POLY(VINYLIDENE FLUORIDE);
D O I
10.1002/adhm.201700845
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Magnetic nanoparticles (NPs) are emerging as an important class of biomedical functional nanomaterials in areas such as hyperthermia, drug release, tissue engineering, theranostic, and lab-on-a-chip, due to their exclusive chemical and physical properties. Although some works can be found reviewing the main application of magnetic NPs in the area of biomedical engineering, recent and intense progress on magnetic nanoparticle research, from synthesis to surface functionalization strategies, demands for a work that includes, summarizes, and debates current directions and ongoing advancements in this research field. Thus, the present work addresses the structure, synthesis, properties, and the incorporation of magnetic NPs in nanocomposites, highlighting the most relevant effects of the synthesis on the magnetic and structural properties of the magnetic NPs and how these effects limit their utilization in the biomedical area. Furthermore, this review next focuses on the application of magnetic NPs on the biomedical field. Finally, a discussion of the main challenges and an outlook of the future developments in the use of magnetic NPs for advanced biomedical applications are critically provided.
引用
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页数:35
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