Controlled release of fluorouracil (5-FU) from chitosan-co-poly(ethylene glycol)/poly(glycerol sebacate)-co-poly(ethylene glycol)-coated iron oxide

被引：9
作者：
Naghizadeh, Shayan [1 ]
Nemati, Nahid Hassanzadeh [1 ]
Najafabadi, Alireza Hassani [2 ,3 ]
Niknejad, Hassan [4 ]
Khani, Mohammad-Mehdi [4 ,5 ]
机构：
[1] Islamic Azad Univ, Sci & Res Branch, Dept Biomed Engn, Tehran, Iran
[2] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Bio Interfaces Inst, Ann Arbor, MI 48109 USA
[4] Shahid Beheshti Univ Med Sci, Med Nanotechnol & Tissue Engn Res Ctr, Tehran, Iran
[5] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Appl Cell Sci, Arabi St,Daneshjoo Blvd, Tehran, Iran
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2018年 / 67卷 / 04期
关键词：
5-FU; Chitosan; drug delivery; nanoparticles; poly(ethylene glycol); poly(glycerol sebacate); SOLUBLE CHITOSAN DERIVATIVES; DRUG-DELIVERY; TARGETING TUMOR; NANOPARTICLES; CELLS; 5-FLUOROURACIL; COMPLEXES; CHITIN;
D O I：
10.1080/00914037.2017.1320657
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A blend of polyglycerol sebacate-poly ethylene glygol/chitosan-poly ethylene glycol-coated iron oxide (PGS-PEG/CS-PEG@Fe3O4) nanoparticles for 5FU delivery was prepared by reverse ultrasonic emulsification method. To enhance polymers' solubility, PEG was grafted. Chemical characterization was performed through Fourier transformed infrared and proton nuclear magnetic resonance spectra. In vitro assay revealed that release profile of 5FU-loaded PGS-PEG/CS-PEG@Fe3O4 is sustained. Moreover, cytotoxicity was analyzed on HT29 cell line at the presence of external magnetic field using the lactate dehydrogenase and Alamar Blue. Results illustrate that (PGS-PEG/CS-PEG@Fe3O4) is promising to use as a carrier for 5FU anticancer agent with sustained tailored release. [GRAPHICS] .
引用
收藏
页码：212 / 220
页数：9
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