Myocardial Perfusion Magnetic Resonance Imaging Using Sliding-Window Conjugate-Gradient Highly Constrained Back-Projection Reconstruction for Detection of Coronary Artery Disease

被引:16
作者
Ma, Heng [1 ,2 ]
Yang, Jun [2 ]
Liu, Jing [2 ]
Ge, Lan [3 ,4 ,5 ]
An, Jing [6 ]
Tang, Qing [7 ]
Li, Han [7 ]
Zhang, Yu [1 ]
Chen, David [3 ,4 ,5 ]
Wang, Yong [8 ]
Liu, Jiabin [1 ]
Liang, Zhigang [1 ]
Lin, Kai [3 ,4 ,5 ]
Jin, Lixin [9 ]
Bi, Xiaoming [10 ]
Li, Kuncheng [1 ]
Li, Debiao [3 ,4 ,5 ]
机构
[1] Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
[2] Yuhuangding Hosp, Yantai, Shandong, Peoples R China
[3] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA USA
[4] Cedars Sinai Med Ctr, Dept Biomed Sci, Biomed Imaging Res Inst, Los Angeles, CA 90048 USA
[5] Cedars Sinai Med Ctr, Dept Imaging, Biomed Imaging Res Inst, Los Angeles, CA 90048 USA
[6] Siemens Healthcare, MR Collaborat NE Asia, Siemens Mindit Magnet Resonance, Shenzhen, Peoples R China
[7] Capital Med Univ, Xuanwu Hosp, Dept Cardiol, Beijing, Peoples R China
[8] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, Shanghai 200092, Peoples R China
[9] Siemens Ltd China, Siemens Healthcare, MR Collaborat NE Asia, Shanghai, Peoples R China
[10] Siemens Healthcare, Cardiovasc MR, R&D, Chicago, IL USA
基金
美国国家卫生研究院; 中国国家自然科学基金;
关键词
DIAGNOSTIC PERFORMANCE; MRI; RESERVE; SENSE; HYPR;
D O I
10.1016/j.amjcard.2011.11.051
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Myocardial perfusion magnetic resonance imaging (MRI) with sliding-window conjugate-gradient highly constrained back-projection reconstruction (SW-CG-HYPR) allows whole left ventricular coverage, improved temporal and spatial resolution and signal/noise ratio, and reduced cardiac motion-related image artifacts. The accuracy of this technique for detecting coronary artery disease (CAD) has not been determined in a large number of patients. We prospectively evaluated the diagnostic performance of myocardial perfusion MRI with SW-CG-HYPR in patients with suspected CAD. A total of 50 consecutive patients who were scheduled for coronary angiography with suspected CAD underwent myocardial perfusion MRI with SW-CG-HYPR at 3.0 T. The perfusion defects were interpreted qualitatively by 2 blinded observers and were correlated with x-ray angiographic stenoses >= 50%. The prevalence of CAD was 56%. In the per-patient analysis, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of SW-CG-HYPR was 96% (95% confidence interval 82% to 100%), 82% (95% confidence interval 60% to 95%), 87% (95% confidence interval 70% to 96%), 95% (95% confidence interval 74% to 100%), and 90% (95% confidence interval 82% to 98%), respectively. In the per-vessel analysis, the corresponding values were 98% (95% confidence interval 91% to 100%), 89% (95% confidence interval 80% to 94%), 86% (95% confidence interval 76% to 93%), 99% (95% confidence interval 93% to 100%), and 93% (95% confidence interval 89% to 97%), respectively. In conclusion, myocardial perfusion MRI using SW-CG-HYPR allows whole left ventricular coverage and high resolution and has high diagnostic accuracy in patients with suspected CAD. (C) 2012 Elsevier Inc. All rights reserved. (Am J Cardiol 2012;109:1137-1141)
引用
收藏
页码:1137 / 1141
页数:5
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