Association of interleukin-13 SNP rs1800925 with allergic rhinitis risk: A meta-analysis based on 1,411 cases and 3169 controls

Studies investigating the association between interleukin-13 (IL-13) single nucleotide polymorphism (SNP) rs1800925 and allergic rhinitis risk have reported conflicting results. The aim of the present study was to conduct a meta-analysis assessing the possible association of IL-13 SNP rs1800925 with allergic rhinitis risk. The relevant studies were identified through a search of PubMed, Embase, ISI Web of Knowledge and Chinese National Knowledge Infrastructure until December 2011 and selected on the basis of the established inclusion criteria for publications. Five studies were included in the present meta-analysis (1411 cases and 3169 controls). The combined results based on all studies showed that IL-13 SNP rs1800925 was not associated with increased allergic rhinitis risk (T versus C: odds ratio (OR) = 1.06, 95% confidence interval (CI) = 0.94-1.20; C/T versus C/C: OR= 1.12,95% CI = 0.97-1.29; T/T versus C/C: OR= 1.00,95% CI =0.69-1.44; C/T + T/T versus CC: OR= 1.10, 95% CI = 0.96-1.27; T/T versus C/C + C/T: OR = 0.91, 95% CI = 0.64-1.31). This meta-analysis supported that IL-13 SNP rs1800925 was not associated with allergic rhinitis. (C) 2012 Elsevier B.V. All rights reserved.